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Characteristics and Trend of Drug-Resistant Tuberculosis at a Major Specialized Hospital in Chongqing, China: 2016 Versus 2019

Published online by Cambridge University Press:  16 May 2022

Huizheng Zhang ,
Ke Zhang ,
Xin Yang ,
Ming Luo ,
Chunhua Li ,
Xiaoying Wang  and
Kui Hu
Huizheng Zhang
Affiliation:
Central Laboratory, Chongqing Public Health Medical Center, Chongqing, China
Ke Zhang
Affiliation:
Department of Anesthesiology, Chongqing University Central Hospital, Chongqing, China School of Nursing, Southwest Medical University, Sichuan, China
Xin Yang
Affiliation:
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Ming Luo
Affiliation:
Central Laboratory, Chongqing Public Health Medical Center, Chongqing, China
Chunhua Li
Affiliation:
Department of Radiology, Chongqing Public Health Medical Center, Chongqing, China
Xiaoying Wang*
Affiliation:
Faculty of Medical Technology, Chongqing Medical and Pharmaceutical College, Chongqing, China
Kui Hu*
Affiliation:
Department of Paediatrics, Dazhou Central Hospital, Sichuan, China
*
Corresponding authors: Xiaoying Wang, Email: diandiewxy@163.com; and Kui Hu, Email: 41593838@qq.com.
Corresponding authors: Xiaoying Wang, Email: diandiewxy@163.com; and Kui Hu, Email: 41593838@qq.com.
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Abstract

Objective:

The epidemic of drug-resistant tuberculosis (DR-TB) has become a major concern in global TB control. This study aimed to investigate the patterns and trend of DR-TB epidemic between different time periods in Chongqing.

Methods:

A total of 985 and 835 culture positive TB patients with drug susceptibility testing (DST) results admitted to the hospital in 2016 and 2019, respectively, were included. Chi-square testing was used to compare the prevalence and trends of DR-TB in 2016 and 2019.

Results:

The proportion of previously treated TB cases with culture positivity was 45.7% in 2019, significantly higher than that in 2016 (39.1%, P = 0.004). The overall rate of drug resistance in 2019 was 43.1%, higher than that in 2016 (40.2%). The rates of multi-drug resistant TB (MDR-TB) and pre-extensively drug resistant TB (pre-XDR-TB) increased significantly from 2016 to 2019 among all TB cases (MDR: 25% vs 33.4%, P < 0.001 and pre-XDR: 7.1% vs 12.8%, P < 0.001, respectively) and previously treated TB cases (MDR: 46.5% vs 56%, P = 0.008 and pre-XDR: 13.2% vs 21.5%, P = 0.003, respectively).

Conclusions:

Our findings indicated that the prevalence of DR-TB remains high in Chongqing. The trend of resistance to anti-TB drugs beccame worse between 2016 and 2019. Moreover, acquired MDR may play a major role in MDR-TB epidemic in Chongqing. Therefore, rapid diagnosis and effective treatment of TB patients will be important to reduce the burden of DR-TB in Chongqing.

Keywords

Chongqingdrug resistancemulti-drug resistancetrendtuberculosis
Type
Original Research
Information
Disaster Medicine and Public Health Preparedness , Volume 17 , 2023 , e169
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of Society for Disaster Medicine and Public Health, Inc.

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