Hostname: page-component-76fb5796d-zzh7m Total loading time: 0 Render date: 2024-04-27T16:59:27.979Z Has data issue: false hasContentIssue false

Disparities in neighbourhood characteristics and 10-year dementia risk by nativity status

Published online by Cambridge University Press:  15 February 2024

R. Wong*
Affiliation:
Department of Public Health and Preventive Medicine, Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA Department of Geriatrics, SUNY Upstate Medical University, Syracuse, NY, USA
D. Soong
Affiliation:
Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA
*
Corresponding author: Roger Wong; Email: WongRo@upstate.edu
Rights & Permissions [Opens in a new window]

Abstract

Aims

Prior research indicates that neighbourhood disadvantage increases dementia risk. There is, however, inconclusive evidence on the relationship between nativity and cognitive impairment. To our knowledge, our study is the first to analyse how nativity and neighbourhood interact to influence dementia risk.

Methods

Ten years of prospective cohort data (2011–2020) were retrieved from the National Health and Aging Trends Study, a nationally representative sample of 5,362 U.S. older adults aged 65+. Cox regression analysed time to dementia diagnosis using nativity status (foreign- or native-born) and composite scores for neighbourhood physical disorder (litter, graffiti and vacancies) and social cohesion (know, help and trust each other), after applying sampling weights and imputing missing data.

Results

In a weighted sample representing 26.9 million older adults, about 9.5% (n = 2.5 million) identified as foreign-born and 24.4% (n = 6.5 million) had an incident dementia diagnosis. Average baseline neighbourhood physical disorder was 0.19 (range 0–9), and baseline social cohesion was 4.28 (range 0–6). Baseline neighbourhood physical disorder was significantly higher among foreign-born (mean = 0.28) compared to native-born (mean = 0.18) older adults (t = −2.4, p = .02). Baseline neighbourhood social cohesion was significantly lower for foreign-born (mean = 3.57) compared to native-born (mean = 4.33) older adults (t = 5.5, p < .001). After adjusting for sociodemographic, health and neighbourhood variables, foreign-born older adults had a 51% significantly higher dementia risk (adjusted hazard ratio = 1.51, 95% CI = 1.19–1.90, p < .01). There were no significant interactions for nativity with neighbourhood physical disorder or social cohesion.

Conclusions

Our findings suggest that foreign-born older adults have higher neighbourhood physical disorder and lower social cohesion compared to native-born older adults. Despite the higher dementia risk, we observed for foreign-born older adults, and this relationship was not moderated by either neighbourhood physical disorder or social cohesion. Further research is needed to understand what factors are contributing to elevated dementia risk among foreign-born older adults.

Type
Original Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press.

Introduction

Previous research has shown a relationship between neighbourhood characteristics and cognitive health among older adults. One study of older adults in the United States (U.S.) found that greater access to parks and greenspaces was independently associated with a 4% significantly greater odds of maintained cognitive function scores over 6 years (Besser et al., Reference Besser, McDonald, Song, Kukull and Rodriguez2017). In contrast, neighbourhood physical disorder at baseline and follow-up was associated with a 10% and 11% increased dementia risk, respectively, during a 9-year window using data from a national U.S. older adult sample (Wong and Wang, Reference Wong and Wang2022). Ultimately, these varying neighbourhood characteristics may influence older adults’ motivation to venture outdoors, thereby altering opportunities for exercise and socialization, both of which are known to aid in maintaining cognitive function during the aging process (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021).

Immigrants (e.g. adults who are foreign-born) often choose to reside in ethnic enclaves, which can potentially offer protective effects against cognitive decline. These enclaves facilitate stronger social connections, a greater sense of community and a supportive environment (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021). However, it is important to note that ethnic enclaves may also be situated in neighbourhoods with higher perceived disorder, characterized by issues such as vandalism, broken curbs and unsafe traffic conditions (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021). These environmental factors can contribute to increased stress levels and potentially exacerbate cognitive conditions (Wong and Wang, Reference Wong and Wang2022).

While new U.S. immigration rates have gradually slowed down over the past decade, the overall immigrant population has continued to grow steadily (Ward and Batalova, Reference Ward and Batalova2023). Notably, the most recent 2020 U.S. Census recorded a historic figure of about 45 million foreign-born individuals in the U.S. (Congressional Budget Office, 2023). Among this population, there are 7.5 million immigrants aged 60 and older, and this number is projected to rise to 20 million by 2050 (Camarota and Zeigler, Reference Camarota and Zeigler2021; Mizoguchi et al., Reference Mizoguchi, Walker, Trevelyan and Ahmed2019). Furthermore, by the year 2060, foreign-born immigrants are estimated to account for nearly a quarter of the U.S. older adult population (Mizoguchi et al., Reference Mizoguchi, Walker, Trevelyan and Ahmed2019).

There are inconclusive findings regarding differences in cognitive impairment risk between foreign-born and native-born groups (Xu et al., Reference Xu, Zhang and Wu2017). Several studies indicate that nativity is not associated with cognitive function. In a cross-sectional sample of older Asian Americans and dementia cases in California, nativity was not shown to change incidence rates for dementia (Hayes-Larson et al., Reference Hayes-Larson, Ikesu, Fong, Mobley, Gee, Brookmeyer, Whitmer, Gilsanz and Mayeda2023). Similarly, a longitudinal study comparing native and foreign-born refugee residents aged 40 years and older in Denmark did not find a relationship between neighbourhood disadvantage and dementia risk (Kim et al., Reference Kim, Foverskov, Frøslev, White, Glymour, Hainmueller, Pedersen, Sørensen and Hamad2022).

Other studies propose that foreign-born individuals may benefit from the ‘healthy immigrant effect’, which suggests that wealthier individuals with more resources are more likely to immigrate, resulting in better health outcomes for immigrants (Markides and Rote, Reference Markides and Rote2019). One study found that the healthy immigrant effect extends to include cognitive benefits in older Mexican Americans (Hill et al., Reference Hill, Angel, Balistreri, Angel, Torres-Gil and Markides2012). Specifically, for those that immigrated between the ages of 20 and 49, immigrants saw a slower decline in cognitive function scores (Hill et al., Reference Hill, Angel, Balistreri, Angel, Torres-Gil and Markides2012).

More recent studies have demonstrated that the healthy immigrant effect diminishes over time due to inherent stresses associated with immigration, such as acculturation, labour-intensive jobs and language barriers, which impede social engagement and access to resources (Markides and Rote, Reference Markides and Rote2019). The cumulative impact of these stresses ultimately has detrimental effects. One study revealed that older immigrants had a 70% higher odds of dementia compared to their native-born U.S. counterparts, after adjusting for demographic, socio-economic and health factors (Franco and Choi, Reference Franco and Choi2020). Further, except for non-Hispanic Black immigrants, those who identified as non-Hispanic White, Hispanic and of other racial and ethnic groups had a higher prevalence of dementia when compared to native-born individuals (Moon et al., Reference Moon, Badana, Hwang, Sears and Haley2019).

Limited research has been conducted on the neighbourhood-cognition relationship between foreign-born and native-born residents. The available studies are limited in scope to a single racial or ethnic group. For example, residing in an ethnic enclave was found to have a protective effect against cognitive decline for foreign-born older Mexican Americans (Weden et al., Reference Weden, Miles, Friedman, Escarce, Peterson, Langa and Shih2017). Conversely, a more recent study revealed that within U.S. Chinese American populations, living in a Chinatown was a risk factor for poorer cognitive function (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021). These inconsistent findings limit generalizability to the broader U.S. population and make it challenging to draw a definitive conclusion regarding the relationship between neighbourhood, nativity and cognition.

Furthermore, the current literature exhibits additional limitations and constraints. Many studies have relied on cross-sectional data, which hinder the ability to establish causal relationships between neighbourhood characteristics and the progression of a disease like dementia (Besser et al., Reference Besser, McDonald, Song, Kukull and Rodriguez2017; Franco and Choi, Reference Franco and Choi2020; Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021; Jia et al., Reference Jia, Du, Chu, Zhang, Fangyu, Lyu, Yan, Zhu, Jiao, Song, Shi, Zhang, Gong, Wei, Tang, Fang, Guo, Wang, Zhou, Chu, Zuo, Yu, Yuan, Wang, Fang, Shi, Yang, Zhou, Liao, Lv, Yan, Kan, Zhao, Wang, Yang, Li, Liu, Wang, Qin, Jia, Quan, Wang, Li, Cao, Xu, Han, Liang, Qiao, Qin and Qiu2020; Moon et al., Reference Moon, Badana, Hwang, Sears and Haley2019; Pase et al., Reference Pase, Rowsthorn, Cavuoto, Lavale, Yassi, Maruff, Buckley and Lim2022). Moreover, previous research has focused on cognitive impairment rather than dementia itself, creating a gap in knowledge regarding the specific effects of neighbourhood and nativity on dementia onset (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021; Hill et al., Reference Hill, Angel, Balistreri, Angel, Torres-Gil and Markides2012; Jia et al., Reference Jia, Du, Chu, Zhang, Fangyu, Lyu, Yan, Zhu, Jiao, Song, Shi, Zhang, Gong, Wei, Tang, Fang, Guo, Wang, Zhou, Chu, Zuo, Yu, Yuan, Wang, Fang, Shi, Yang, Zhou, Liao, Lv, Yan, Kan, Zhao, Wang, Yang, Li, Liu, Wang, Qin, Jia, Quan, Wang, Li, Cao, Xu, Han, Liang, Qiao, Qin and Qiu2020; Weden et al., Reference Weden, Miles, Friedman, Escarce, Peterson, Langa and Shih2017). These limitations highlight the need for longitudinal studies that specifically investigate the relationship between neighbourhood factors, nativity and dementia progression.

Our present study addresses these gaps and limitations by analysing 10 years of prospective longitudinal data. To the best of our knowledge, our study is the first to examine how neighbourhood characteristics interact with nativity to influence dementia risk using a national U.S. older adult sample. Our specific objectives include the following: (1) examine how nativity status is associated with dementia risk among older adults, (2) examine differences in neighbourhood physical disorder and social cohesion by nativity status among older adults and (3) examine how neighbourhood moderates the relationship between nativity status and dementia risk among older adults.

Methods

Data source

Data were retrieved from the National Health and Aging Trends Study (NHATS), a longitudinal panel study that surveys a nationally representative sample of Medicare beneficiaries aged 65 years and older within the U.S. Ten annual waves between 2011 and 2020 of the NHATS were analysed for this study. Full details on NHATS data collection procedures and sampling methods are described elsewhere (Freedman et al., Reference Freedman, Schrack, Skehan and Kasper2022). From the initial sample of 8,245 respondents in the 2011 NHATS cohort, we sequentially excluded respondents who were not community-dwelling (n = 1,048) and had a pre-existing dementia diagnosis (n = 1,835). Therefore, our final sample included 5,362 community-dwelling older adults at baseline without a prior dementia diagnosis, described later below.

Nativity measure

The nativity variable was derived from the question, ‘Were you born in the U.S.?’. A ‘yes’ response was coded as native-born, and a ‘no’ response was coded as foreign-born.

Neighbourhood measures

Neighbourhood characteristics were physical disorder and social cohesion, which were each measured with separate composite scores. These composite scores were developed in the same approach used previously in a separate study using the NHATS data (Wong and Wang, Reference Wong and Wang2022) and similar to the Population Study of Chinese Elderly data (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021), which revealed sufficient validity for both neighbourhood physical disorder (α = 0.80) and social cohesion (α = 0.86). The neighbourhood physical disorder composite score was developed from a three-item home environment questionnaire: litter, graffiti and vacancies. For each item, the NHATS interviewer was asked to rate their agreement (none, a little, some or a lot) when standing in front of the respondent’s home/building and looking around in every direction. Litter was defined as ‘Litter, broken glass or trash on sidewalks and streets’. Graffiti was defined as ‘Graffiti on buildings and walls’. Vacancies were defined as ‘Vacant or deserted houses or storefronts’. After combining these three measures, physical disorder composite scores ranged from 0 to 9, with higher values indicating neighbourhoods with more physical disorder.

Similarly, the neighbourhood social cohesion composite score was developed from a three-item community environment questionnaire: knowing, helping and trusting. For each item, respondents were asked to rate their agreement (do not agree, agree a little or agree a lot). Knowing was asked as ‘People in this community know each other very well’. Helping was asked as ‘People in this community are willing to help each other’. Trusting was asked as ‘People in this community can be trusted’. After combining these three measures, social cohesion composite scores ranged from 0 to 6, with higher values indicating neighbourhoods with more social cohesion.

Similar to the approach used previously from a separate study using neighbourhood measures in the NHATS data (Wong and Wang, Reference Wong and Wang2022), we constructed composite scores for physical disorder and social cohesion at baseline (2011) and follow-up (year before death, drop-out or dementia). For both the physical disorder and social cohesion variables, a change variable was also computed by subtracting the follow-up score from the baseline score. Therefore, physical disorder change had a range from −9 to +9, with higher values indicating more disorder at follow-up compared to baseline. Likewise, social cohesion change had a range from −6 to +6, with higher values indicating more cohesion at follow-up compared to baseline. The regression models included only the baseline and change composite scores to limit multicollinearity due to a high correlation between follow-up and change scores.

Dementia measure

The dependent variable was incident dementia diagnosis, which occurred during the period between 2012 and 2020, after the exclusion of pre-existing dementia diagnoses at baseline (2011). Dementia diagnosis was derived from an NHATS algorithm (Kasper et al., Reference Kasper, Freedman and Spillman2013) that uses three cognitive measures: (1) AD8 Dementia Screening Interview, (2) cognitive tests that evaluate the respondents’ memory (e.g. immediate 10-word recall), orientation (e.g. date) and executive function (e.g. clock drawing test) and (3) self-report of an Alzheimer’s or dementia diagnosis by a doctor. From these cognitive measures, the NHATS algorithm generated a binary dementia diagnosis (probable or possible), which has been validated to have a high sensitivity of 85.7% and high specificity of 83.7% (Kasper et al., Reference Kasper, Freedman and Spillman2013).

Covariates

Regression models were adjusted for sociodemographic and health variables. Sociodemographic variables included age, sex (male or female), race and ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, Asian or Other), highest level of education (less than high school, high school or college), total income, marital status (married or unmarried) and metropolitan residence (metro or non-metro). Health variables included self-rated health (poor to excellent), body mass index (BMI), limitations for activities of daily living (no ADL limitations or at least one ADL limitation), proxy respondent, major depressive disorder, generalized anxiety disorder, heart attack history, hypertension history, diabetes history and stroke history.

Analysis plan

Descriptive statistics for continuous variables were reported as mean and standard deviation, whereas categorical variables were reported as frequencies and proportions. Differences in average neighbourhood physical disorder and social cohesion by nativity status were analysed using one-way analysis of variance (ANOVA) tests. We used Cox proportional hazards models to analyse time (number of years) to dementia diagnosis starting from baseline (2011). All regression models applied complex survey sampling weights and adjusted for sociodemographics and health. About 15% of the sample was lost through listwise deletion. To maximize the full number of respondents in the data set and minimize bias due to missing data, we used multiple imputation by chained equation (MICE) to generate 15 imputed data files with 10 iterations each. We performed a sensitivity analysis comparing results from MICE versus listwise deletion. Statistical analyses were performed in Stata 18 with two-tailed tests at a 0.05 significance level.

Results

Sample characteristics

After applying survey sampling weights, the 5,362 NHATS respondents represented 26,851,237 older adults in the U.S. population. Among the respondents, 9.5% (n = 2.5 million) identified as foreign-born in the weighted sample, which is comparable to 9.3% (n = 492) in the unweighted sample. Additionally, approximately 24.4% (n = 6.5 million) of the respondents had an incident dementia diagnosis between 2012 and 2020. The mean age of the sample population was 73.8 years. The majority of the respondents were female (56.2%), non-Hispanic White (84.1%), married (61.7%) and resided in a metropolitan area (81.4%). On average, respondents reported a yearly income of about $64,000.

The native-born population primarily consisted of non-Hispanic White individuals (88.8%), whereas the foreign-born population was more diverse, with a higher representation of Hispanic (36%) and Asian (16%) older adults (F = 286.47, p < .001). Foreign-born individuals were in general significantly more likely than native-born individuals to have lower levels of education (F = 15.15, p < .001). Moreover, a higher proportion of foreign-born individuals (93.3%) resided in metropolitan areas compared to native-born individuals (80.1%) (F = 9.08, p < .01).

As indicated in Table 1, most respondents rated their health as good. Only a minority reported limitations in ADL (1.4%), had a proxy respondent (1.4%) or experienced depression (10.9%), anxiety (9.9%), diabetes (22.2%), heart attack (12.3%) or stroke (9.8%). However, a substantial proportion of respondents had hypertension (63.4%) and were overweight, with an average BMI of 27.9.

Table 1. Weighted sample characteristicsa

a Unless otherwise indicated, data are expressed as percent and frequency (in millions).

b T-test for continuous variables and chi-square for categorical variables.

c Physical disorder at baseline and follow-up has a range from 0 to 9, with higher values indicating more disorder. Physical disorder change has a range from −9 to +9, with higher values indicating more disorder at follow-up compared to baseline. Follow-up refers to year before death, drop-out or dementia.

d Social cohesion at baseline and follow-up has a range from 0 to 6, with higher values indicating more cohesion. Social cohesion change has a range from −6 to +6, with higher values indicating more cohesion at follow-up compared to baseline. Follow-up refers to year before death, drop-out or dementia.

Significant differences were observed between foreign-born and native-born individuals in several health indicators. Foreign-born individuals were significantly more likely to have ADL limitations (F = 19.98, p < .001), a proxy respondent (F = 41.90, p < .001) and depression (F = 5.93, p < .02) compared to native-born individuals. However, they exhibited a lower prevalence of previous strokes (F = 1.66, p = .02) and lower average BMI (t = 4.17, p < .001).

Neighbourhood differences by nativity

The relationship between nativity and neighbourhood characteristics was examined at both baseline and follow-up (Table 1). Physical disorder was significantly higher among foreign-born individuals compared to native-born individuals at both baseline (t = −2.40, p = .02) and follow-up (t = −3.26, p < .01). Social cohesion, conversely, was significantly lower among foreign-born individuals compared to native-born individuals at both baseline (t = 5.50, p < .001) and follow-up (t = 4.68, p < .001). However, when examining the change between baseline and follow-up for both physical disorder and social cohesion, no statistically significant differences were found after stratifying by nativity.

Cox regression results

Our unadjusted crude model indicated that foreign-born status was significantly associated with an 82% increased dementia risk (hazard ratio = 1.82, 95% CI = 1.60–2.08, p < .001) (Table 2, Model A). After adjusting for sociodemographics and health, foreign-born older adults maintained a 49% significant increased dementia risk (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.19–1.87, p < .01) (Table 2, Model B). In our fully-adjusted model, nativity status was again significantly associated with dementia diagnosis, with those who were foreign-born having a 51% higher increased risk (aHR = 1.51, 95% CI = 1.19–1.90, p < .01).

Table 2. Weighted cox regression of nativity and neighbourhood on dementia risk

Additionally, it was observed that both physical disorder at baseline (aHR = 1.15, 95% CI = 1.05–1.25, p < .001) and the change in physical disorder (aHR = 1.14, 95% CI = 1.06–1.22, p < .01) were significantly associated with an increased dementia risk. However, neither baseline neighbourhood social cohesion (aHR = 1.02, 95% CI = 0.98–1.06, p = .31) nor change in social cohesion (aHR = 1.03, 95% CI = 0.99–1.07, p = .21) was significantly associated with dementia risk.

Moderation test

In our interaction model (Table 2, Model D), we found that neighbourhood physical disorder and social cohesion did not significantly moderate the relationship between nativity and dementia risk. In a sensitivity analysis with the listwise deletion model, physical disorder change was a significant moderator (data not shown). Compared to native-born older adults, higher physical disorder at follow-up versus baseline decreased dementia risk for foreign-born older adults (aHR = 0.78, 95% CI = 0.63–0.98, p = .03).

Discussion

In our study, we observed that foreign-born older adults in the U.S. had a higher risk of developing dementia compared to their native-born counterparts. Prior research investigating the association between nativity and dementia has yielded inconsistent results. Some studies have been limited in scope, focusing on a specific race or ethnicity (Guo et al., Reference Guo, Wang, Xu, Li, Wu and Dong2021; Weden et al., Reference Weden, Miles, Friedman, Escarce, Peterson, Langa and Shih2017), while others have faced limitations in sample size (Kim et al., Reference Kim, Foverskov, Frøslev, White, Glymour, Hainmueller, Pedersen, Sørensen and Hamad2022). However, our findings align with a recent study that analysed our same NHATS data and concluded that older immigrants had a 70% greater odds of having dementia (Franco and Choi, Reference Franco and Choi2020). We expanded on their cross-sectional study using the 2011 NHATS data by using 10 years (2011–2020), and our prospective longitudinal study provides further support suggesting that foreign-born older adults may have an increased dementia risk.

One possible explanation for the heightened risk of dementia among older immigrants is their chronic exposure to stress and discrimination, which can manifest in various forms and affect multiple aspects of their lives (Higuera and Jiménez, Reference Higuera and Jiménez2023). Discrimination-induced stress inhibits their ability to establish a sense of security and stability in their host country (Higuera and Jiménez, Reference Higuera and Jiménez2023). Certain characteristics of immigrants, such as skin tone or limited language skills, which are often difficult or impossible to change, have consistently been associated with increased discrimination in social interactions (Szaflarski and Bauldry, Reference Szaflarski and Bauldry2019). This discriminatory treatment extends to the workplace, where immigrants, particularly Hispanic individuals, encounter limited job opportunities (Bradley-Geist and Schmidtke, Reference Bradley-Geist, Schmidtke, Colella and King2017). They frequently find themselves in labour-intensive and hazardous positions, which not only impede upward mobility but also expose them to exploitation and the constant fear of immigration raids (Pourat et al., Reference Pourat, Young, Morales and Chen2021).

Discrimination has been widely linked to adverse outcomes in physical, mental and cognitive health. A recent study discovered that lifetime experiences of discrimination were associated with a 40% increased risk of developing dementia (Bancks et al., Reference Bancks, Byrd, Caban‐Holt, Fitzpatrick, Forrester, Hayden, Heckbert, Kershaw, Rapp, Sachs and Hughes2023). Research also indicates that discrimination and dementia risk are not contingent on race or ethnicity, exposing all immigrants who face discrimination to an elevated risk (Bancks et al., Reference Bancks, Byrd, Caban‐Holt, Fitzpatrick, Forrester, Hayden, Heckbert, Kershaw, Rapp, Sachs and Hughes2023; Dark et al., Reference Dark, Huang, Cordon, Deal, Palta, Windham, Barnes, Kucharska‐Newton, Mosley, Gottesman, Sims, Griswold, Arce Rentería, Manly and Walker2023). Ultimately, chronic stress can contribute to the exacerbation of clinical signs commonly associated with dementia, such as high blood pressure (Dolezsar et al., Reference Dolezsar, McGrath, Herzig and Miller2014).

Our study revealed noteworthy findings regarding foreign-born older adults and their living conditions. Firstly, respondents were significantly more likely to reside in neighbourhoods with higher levels of physical disorder at both baseline and follow-up. This trend may be attributed, in part, to a higher proportion of foreign-born individuals living in metropolitan areas, where indicators of physical disorder, such as graffiti and broken curbs, were more prevalent. Additionally, our results indicate that foreign-born older adults generally achieved lower levels of education compared to their native-born counterparts, potentially resulting in lower socio-economic status and residing in more disadvantaged neighbourhoods with higher physical disorder (Doerschuk et al., Reference Doerschuk, Bahrim, Daniel, Kruger, Mann and Martin2016).

Contrary to our initial hypothesis, which proposed that foreign-born adults might be more likely to reside in ethnic enclaves that foster social connections, our findings demonstrated that the participants in our study reported lower levels of social cohesion. One plausible explanation for this discrepancy is that since foreign-born older adults were also more likely to live in neighbourhoods with higher physical disorder, the environment likewise becomes less of a conducive space for social interactions (Choi and Matz-Costa, Reference Choi and Matz-Costa2017; Zahnow et al., Reference Zahnow, Corcoran, Kimpton and Wickes2022). This, coupled with the challenges foreign-born older adults face in mastering second language skills, may create barriers that hinder their ability to form social connections with their neighbours (Maleku et al., Reference Maleku, Kim and Lee2019).

These findings have significant implications for stakeholders, including healthcare professionals, who should be aware of the increased vulnerability of foreign-born older adults to dementia to ensure accurate diagnosis and appropriate care (Franco and Choi, Reference Franco and Choi2020). This is especially critical given that there is currently no cure for dementia, and regular screening is essential to identify early signs of cognitive impairment for FDA-approved treatments to most effectively slow disease progression (Alzheimer’s Association, 2023). Policymakers should prioritize immigrant health by allocating resources to invest in immigrant neighbourhoods, with a focus on reducing physical disorder, which has been associated with increased dementia risk over time (Wong and Wang, Reference Wong and Wang2022).

Future research is needed to explore the underlying reasons behind the observed relationship between nativity and dementia. This may include developing partnerships between patients, family members (e.g. caregiver or translator), researchers and clinicians to engage foreign-born adults in biomedical research (Wong et al., Reference Wong, Grullon, McNamara, Smith, Dillenbeck, Royal and Brangman2023), which has been shown to be one of the most effective strategies to recruit and retain underrepresented populations in dementia research (Wong et al., Reference Wong, Amano, Lin, Zhou and Morrow-Howell2019). Understanding the factors that place foreign-born older adults at a higher risk of developing dementia can inform more effective prevention and intervention strategies. Additionally, studying the factors influencing the residential patterns of foreign-born older adults, including physical disorder and social cohesion in their neighbourhoods, can lead to informed policies that promote better physical, mental and cognitive health for this population.

There are several notable limitations in our study. Foreign-born is a heterogenous group, and we do not have data on the native country for respondents born outside the U.S. Similarly, we did not account for the length of residence in the U.S. since immigrating. However, we believe this may have a minimal impact given that our respondents are beneficiaries of Medicare, which requires at least 5 years of continuous residence in the U.S. before enrolment. Although all our research questions and analyses were planned before viewing the results, we did not publish a protocol. Finally, it is possible that our dementia risk estimates are biased because we censored respondents who died, instead of accounting for this competing risk. Despite these limitations, our study is an important contribution to the literature and addresses multiple knowledge gaps by investigating the relationship between nativity, neighbourhood and dementia using a nationally representative and prospective sample from a 10-year window.

Conclusions

Our study provides valuable insights into the increased risk of dementia among older immigrants. Residing in disadvantaged neighbourhoods may contribute to increased chronic stress, highlighting the importance of public health initiatives aimed at improving living conditions. Developmental investments that enhance quality of life and promote socio-economic growth, such as the creation of parks and retail shopping centres, may be effective strategies (Zahnow et al., Reference Zahnow, Corcoran, Kimpton and Wickes2022). However, further research is needed to identify the specific mechanisms underlying the increased dementia risk among older immigrants. Understanding these mechanisms will support the development of targeted interventions and action plans to reduce dementia incidence within this vulnerable population.

Availability of data and materials

Data sharing is not available because this study received approval to analyse sensitive data from the NHATS. Researchers interested in obtaining this data may submit a Sensitive Data Application to NHATS: https://nhats.org/researcher/data-access.

Acknowledgements

National Health and Aging Trends Study data are sponsored by the National Institute on Aging (Grant Number U01AG32947) and were conducted by Johns Hopkins University.

Author contributions

RW conceived the study and conducted the analysis. DS critically contributed to data interpretation. All authors drafted the manuscript and approved the final submitted version.

Financial support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Competing interests

None.

Ethical standards

This study was approved by the SUNY Upstate Institutional Review Board for the Protection of Human Subjects (#2064213-1).

References

Alzheimer’s Association (2023) 2023 Alzheimer’s disease facts and figures. Alzheimers & Dementia 19, 15981695.CrossRefGoogle Scholar
Bancks, MP, Byrd, GS, Caban‐Holt, A, Fitzpatrick, AL, Forrester, SN, Hayden, KM, Heckbert, SR, Kershaw, KN, Rapp, SR, Sachs, BC and Hughes, TM (2023) Self‐reported experiences of discrimination and incident dementia. Alzheimers & Dementia 19(7), .CrossRefGoogle ScholarPubMed
Besser, LM, McDonald, N, Song, Y, Kukull, WA and Rodriguez, DA (2017) Neighborhood environment and cognition in older adults: A systematic review. American Journal of Preventive Medicine 53(2), 241251.CrossRefGoogle ScholarPubMed
Bradley-Geist, J and Schmidtke, J (2017) The Oxford Handbook of Workplace Discrimination, eds. Colella, A and King, E. New York, NY: Oxford University Press, 159175.Google Scholar
Camarota, SA and Zeigler, K (2021) Immigrants coming to America at older ages, CIS.org. https://cis.org/Report/Immigrants-Coming-America-Older-Ages (accessed 15 July 2023).Google Scholar
Choi, YJ and Matz-Costa, C (2017) Perceived neighborhood safety, social cohesion, and psychological health of older adults. The Gerontologist 58(1), .Google Scholar
Congressional Budget Office (2023) The foreign-born population, the U.S. economy, and the federal budget.Google Scholar
Dark, HE, Huang, A, Cordon, J, Deal, JA, Palta, P, Windham, BG, Barnes, LL, Kucharska‐Newton, A, Mosley, T, Gottesman, RF, Sims, M, Griswold, M, Arce Rentería, M, Manly, JJ and Walker, KA (2023) The association of perceived discrimination with dementia risk in Black older adults. Alzheimers & Dementia 19, 43464356.CrossRefGoogle ScholarPubMed
Doerschuk, P, Bahrim, C, Daniel, J, Kruger, J, Mann, J and Martin, C (2016) Closing the gaps and filling the STEM pipeline: A multidisciplinary approach. Journal of Science Education and Technology 25(4), 682695.CrossRefGoogle Scholar
Dolezsar, CM, McGrath, JJ, Herzig, AJM and Miller, SB (2014) Perceived racial discrimination and hypertension: A comprehensive systematic review. Health Psychology 33(1), 2034.CrossRefGoogle ScholarPubMed
Franco, Y and Choi, EY (2020) The relationship between immigrant status and undiagnosed dementia: The role of limited English proficiency. Journal of Immigrant & Minority Health 22(5), 914922.CrossRefGoogle ScholarPubMed
Freedman, VA, Schrack, JA, Skehan, ME and Kasper, JD (2022) NHATS user guide: Rounds 1-11 final release.Google Scholar
Guo, M, Wang, Y, Xu, H, Li, M, Wu, B and Dong, X (2021) Is living in an ethnic enclave associated with cognitive function? Results from the Population Study of Chinese Elderly (PINE) in Chicago. The Gerontologist 62(5), 662673.CrossRefGoogle Scholar
Hayes-Larson, E, Ikesu, R, Fong, J, Mobley, TM, Gee, GC, Brookmeyer, R, Whitmer, RA, Gilsanz, P and Mayeda, ER (2023) Association of education with dementia incidence stratified by ethnicity and nativity in a cohort of older Asian American individuals. JAMA Network Open 6(3), .CrossRefGoogle Scholar
Higuera, K and Jiménez, TR (2023) Mechanism mapping: A qualitative study of how different forms of instability mediate the relationship between legal status and immigrant mental well-being. Social Science & Medicine 329, .CrossRefGoogle ScholarPubMed
Hill, TD, Angel, JL and Balistreri, KS (2012) Does the “healthy immigrant effect” extend to cognitive aging? In Angel, JL, Torres-Gil, F and Markides, K (eds), Aging, Health, and Longevity in the Mexican-Origin Population. Boston, MA: Springer US, 1933.CrossRefGoogle Scholar
Jia, L, Du, Y, Chu, L, Zhang, Z, Fangyu, L, Lyu, D, Yan, L, Zhu, M, Jiao, H, Song, Y, Shi, Y, Zhang, H, Gong, M, Wei, C, Tang, Y, Fang, B, Guo, D, Wang, F, Zhou, A, Chu, C, Zuo, X, Yu, Y, Yuan, Q, Wang, W, Fang, L, Shi, S, Yang, H, Zhou, C, Liao, Z, Lv, Y, Yan, L, Kan, M, Zhao, H, Wang, S, Yang, S, Li, H, Liu, Z, Wang, Q, Qin, W, Jia, J, Quan, M, Wang, Y, Li, W, Cao, S, Xu, L, Han, Y, Liang, J, Qiao, Y, Qin, Q and Qiu, Q (2020) Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: A cross-sectional study. The Lancet Public Health 5(12), e661e671.CrossRefGoogle ScholarPubMed
Kasper, JD, Freedman, VA and Spillman, B (2013) Classification of persons by dementia status in the National Health and Aging Trends Study.Google Scholar
Kim, MH, Foverskov, E, Frøslev, T, White, JS, Glymour, MM, Hainmueller, J, Pedersen, L, Sørensen, HT and Hamad, R (2022) Neighborhood disadvantage and the risk of dementia and mortality among refugees to Denmark: A quasi-experimental study. SSM - Population Health 21, .Google ScholarPubMed
Maleku, A, Kim, YK and Lee, G (2019) Social cohesion and immigrant health: Does language-efficacy matter? International Journal of Migration, Health and Social Care 15(1), 1730.CrossRefGoogle Scholar
Markides, KS and Rote, S (2019) The healthy immigrant effect and aging in the United States and other western countries. The Gerontologist 59(2), 205214.CrossRefGoogle ScholarPubMed
Mizoguchi, N, Walker, L, Trevelyan, E and Ahmed, B (2019) The older foreign-born population in the United States: 2012–2016.Google Scholar
Moon, H, Badana, ANS, Hwang, S-Y, Sears, JS and Haley, WE (2019) Dementia prevalence in older adults: Variation by race/ethnicity and immigrant status. The American Journal of Geriatric Psychiatry 27(3), 241250.CrossRefGoogle Scholar
Pase, MP, Rowsthorn, E, Cavuoto, MG, Lavale, A, Yassi, N, Maruff, P, Buckley, RF and Lim, YY (2022) Association of neighborhood-level socioeconomic measures with cognition and dementia risk in Australian adults. JAMA Network Open 5(3), .CrossRefGoogle ScholarPubMed
Pourat, N, Young, M-E, Morales, B and Chen, L (2021) UCLA center for health policy research. https://healthpolicy.ucla.edu/publications/search/pages/detail.aspx?PubID=2223 (accessed 15 July 2023).Google Scholar
Szaflarski, M and Bauldry, S (2019) The effects of perceived discrimination on immigrant and refugee physical and mental health. Advances in Medical Sociology 19, 173204.CrossRefGoogle ScholarPubMed
Ward, N and Batalova, J (2023) Frequently requested statistics on immigrants and immigration in the United States, migrationpolicy.org. https://www.migrationpolicy.org/article/frequently-requested-statistics-immigrants-and-immigration-united-states (accessed 16 June 2023).Google Scholar
Weden, MM, Miles, JNV, Friedman, E, Escarce, J, Peterson, C, Langa, KM and Shih, RA (2017) The Hispanic paradox: Race/ethnicity and nativity, immigrant enclave residence and cognitive impairment among older US adults. Journal of the American Geriatrics Society 65(5), 10851091.CrossRefGoogle Scholar
Wong, R, Amano, T, Lin, SY, Zhou, Y and Morrow-Howell, N (2019) Strategies for the recruitment and retention of racial/ethnic minorities in Alzheimer disease and dementia clinical research. Current Alzheimer Research 16(5), 458471.CrossRefGoogle ScholarPubMed
Wong, R, Grullon, JR, McNamara, SE, Smith, NH, Dillenbeck, CA, Royal, K and Brangman, SA (2023) Multi-sectoral collaborations to increase recruitment and retention of diverse older adults in biomedical research. The Journals of Gerontology: Series A.Google Scholar
Wong, R and Wang, Y (2022) Role of neighborhood physical disorder and social cohesion on racial and ethnic disparities in dementia risk. Journal of Aging and Health 34(9–10), 11781187.CrossRefGoogle ScholarPubMed
Xu, H, Zhang, Y and Wu, B (2017) Association between migration and cognitive status among middle-aged and older adults: A systematic review. BMC Geriatrics 17(1), .CrossRefGoogle ScholarPubMed
Zahnow, R, Corcoran, J, Kimpton, A and Wickes, R (2022) Neighbourhood places, collective efficacy and crime: A longitudinal perspective. Urban Studies 59(4), 789809.CrossRefGoogle Scholar
Figure 0

Table 1. Weighted sample characteristicsa

Figure 1

Table 2. Weighted cox regression of nativity and neighbourhood on dementia risk