This paper summarizes the best available information on the nature and prevalence of drug-facilitated sexual assault (DFSA) in the UK. Characteristics of the assault itself and the drugs used are described. The minimal available data on the psychological consequences of DFSA are considered. Our clinical experience suggests that DFSA has some psychological consequences that are distinct from those seen in sexual assault without drug involvement. The survivor's response to a fragmented or absent traumatic memory appears important. We suspect that specific characteristics of the assault (for example, obvious premeditation) may affect adjustment. Also, the involvement of alcohol, drugs and an incomplete memory in the survivor's account may affect the levels of validation and social support received. We review the model of post-trauma reactions that seems most useful in treating the consequences of DFSA and suggest additional treatment strategies that address the specific nature of this trauma.