3 results
Contributors
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- By Sofya Abazyan, Saskia S. Arndt, Jonathon C. Arnold, Sandra Beeské, Odd-Geir Berge, Valerie J. Bolivar, David Borchelt, Marie-Françoise Chesselet, Yoon H. Cho, Angelo Contarino, John C. Crabbe, Wim E. Crusio, Bianca De Filippis, Mara Dierssen, Stephanie C. Dulawa, Emily C. Eastwood, Haim Einat, Raul R. Gainetdinov, David Gordon, Guy Griebel, F. Scott Hall, John H. Harkness, Christopher Janus, Zhengping Jia, Nirit Kara, Tim Karl, Martien J. H. Kas, Federica Klaus, Robert Lalonde, Glenda Lassi, Giovanni Laviola, Iddo Magen, Stephen C. Maxson, Douglas Ashley Monks, Rebecca E. Nordquist, Lucy R. Osborne, Tamara J. Phillips, Alisdair R. Philp, Marina R. Picciotto, Susanna Pietropaolo, Mikhail V. Pletnikov, Christopher R. Pryce, James L. Resnick, Laura Ricceri, Frans Sluyter, Emily Y. Smith, Ichiro Sora, Tatyana D. Sotnikova, Rebecca C. Steiner, Ortrud K. Steinlein, Catherine Strazielle, Enejda Subashi, Ashlyn Swift-Gallant, Aki Takahashi, Kevin Talbot, Stewart Thompson, Valter Tucci, F. Josef van der Staay, Gertjan van Dijk, Nancy S. Woehrle
- Edited by Susanna Pietropaolo, Centre National de la Recherche Scientifique (CNRS), Paris, Frans Sluyter, University of Portsmouth, Wim E. Crusio, Centre National de la Recherche Scientifique (CNRS), Paris
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- Book:
- Behavioral Genetics of the Mouse
- Published online:
- 05 October 2014
- Print publication:
- 25 September 2014, pp ix-xii
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List of contributors
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- By Nazia M. Alam, Enrico Alleva, Hiroyuki Arakawa, Robert H. Benno, Fred G. Biddle, D. Caroline Blanchard, Robert J. Blanchard, Richard J. Bodnar, John D. Boughter, Igor Branchi, Richard E. Brown, Abel Bult-Ito, Jonathan M. Cachat, Peter R. Canavello, Francesca Cirulli, Giovanni Colacicco, John C. Crabbe, Jacqueline N. Crawley, Wim E. Crusio, Sietse F. de Boer, Ekrem Dere, Brenda A. Eales, Robert T. Gerlai, Howard K. Gershenfeld, Thomas J. Gould, Martin E. Hahn, Peter C. Hart, Andrew Holmes, Joseph P. Huston, Allan V. Kalueff, Benjamin Kest, Robert Lalonde, Sarah R. Lewis-Levy, Hans-Peter Lipp, Sheree F. Logue, Stephen C. Maxson, Jeffrey S. Mogil, Douglas A. Monks, Dennis L. Murphy, Lee Niel, Timothy P. O’Leary, Susanna Pietropaolo, Peter K.D. Pilz, Claudia F. Plappert, Bernard Possidente, Glen T. Prusky, Laura Ricceri, Heather Schellinck, Herbert Schwegler, Burton Slotnick, Frans Sluyter, Shad B. Smith, Catherine Strazielle, Douglas Wahlsten, Hans Welzl, James F. Willott, David P. Wolfer, Armin Zlomuzica
- Edited by Wim E. Crusio, Université de Bordeaux, Frans Sluyter, Robert T. Gerlai, University of Toronto, Susanna Pietropaolo, Université de Bordeaux
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- Book:
- Behavioral Genetics of the Mouse
- Published online:
- 05 May 2013
- Print publication:
- 25 April 2013, pp ix-xii
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8 - Grooming after cerebellar, basal ganglia, and neocortical lesions
- Edited by Allan V. Kalueff, National Institute of Mental Health, Washington DC, Justin L. La Porte, National Institute of Mental Health, Washington DC, Carisa L. Bergner, National Institute of Mental Health, Washington DC
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- Book:
- Neurobiology of Grooming Behavior
- Published online:
- 04 August 2010
- Print publication:
- 20 May 2010, pp 145-155
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Summary
Summary
Electrical stimulation of the midline cerebellum and striatum elicits grooming in rats. Lesioning methods with either surgery or genetic mutations indicate that these brain regions contribute to grooming behaviors. Grid2Lc mutant mice with selective cerebellar atrophy and Girk2Wv mutants with combined cerebellar and substantia nigra atrophy display different effects on grooming. While Grid2Lc mutants were affected in grooming completion but not serial ordering, the reverse was true in Girk2Wv mutants. Our results implicate cerebello–neocortical pathways in the completion of grooming chains, and a striato–pallido–neocortical pathway in the serial ordering of grooming chains.
Introduction and methodological considerations
The role of the cerebellum and basal ganglia on grooming is of some importance considering that grooming implies movement. It is therefore expected that part of the neural circuitry underlying grooming involves some aspect of motor function. In view of the importance of the cerebellum and basal ganglia in balance and posture (Lalonde and Strazielle 2007a), there is a special challenge in interpreting lesion effects of these brain regions on grooming. This is achievable by measuring serial ordering of grooming sequences. It is well established that rodents groom in a cephalocaudal order, anterior before posterior body parts (Richmond and Sachs 1980; Sachs 1988). Different types of grooming components may also be measured, such as face washing; licking of forelimbs, abdomen, back, and hindlimbs; as well as body shaking and scratching (Vanderwolf et al. 1978). Lesions may selectively affect some grooming components in a fashion inexplainable by motor deficits.