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2 - Immunology of toxoplasma infection
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- By C. A. Hunter, Department of Pathobiology, University of Pennsylvania, Philadelphia, USA, G. Reichmann, Institute for Medical Microbiology and Virology, Heinrich-Heine University, Dusseldorf, Germany
- Edited by David H. M. Joynson, Singleton Hospital, Swansea, Tim G. Wreghitt, Addenbrooke's Hospital, Cambridge
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- Book:
- Toxoplasmosis
- Published online:
- 24 September 2009
- Print publication:
- 04 October 2001, pp 43-57
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- Chapter
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Summary
Pathogenesis of toxoplasmosis
The infection of immunocompetent individuals with Toxoplasma gondii most often results in an asymptomatic infection or occasionally in an infectious mononucleosis-type illness (Luft & Remington 1988). However, clinical toxoplasmosis is frequently associated with immune-deficient individuals and maternal–foetal transmission of this parasite causes congenital disease (Remington et al. 1994). In order to appreciate the disease caused by T. gondii it is important to have an understanding of the basic biology of this infection and how protective immunity to this parasite is mediated. The ability of the tachyzoite stage of the parasite to invade any nucleated cell, replicate and then lyse the host cell before invading neighbouring cells is an important element that underlies the pathogenesis of this cytolytic infection. In the absence of a protective immune response, the parasite will replicate in an unrestricted manner and destroy infected tissues. Moreover, since the tachyzoite stage of the parasite is intracellular, it is protected from the effects of the humoral immune response. As a consequence, the protective response needed to control this parasite is dominated by cell-mediated immunity, and in particular the production of the cytokine interferon-γ (IFN-γ). The events that lead to the production of IFN-γ and its protective effects are discussed in greater detail below.
The presence of a ‘latent’ stage of T. gondii in the infected host also represents an important aspect of toxoplasmosis. Tachyzoites can transform into bradyzoites which are found within cysts in many tissues, but in particular the brain and muscle.