The way spoken language is represented by orthographic structure is thought to influence the cognitive reading mechanism for a language, and therefore language breakdown patterns should reflect this. The present article focuses on two patients, both monolingual native Spanish speakers, who were able to read words but showed great difficulty in reading nonwords. This finding could be attributed to the fact that these patients were reading globally using a lexical route. This pattern of reading behavior is known as phonological dyslexia. It has been argued that lexical reading is not an option for Spanish readers since its orthography is highly regular. Our findings contradict this hypothesis and support the view that cognitive reading mechanisms are universal.