2 results
The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression
- Vincent Van den Eynde, Wegdan R. Abdelmoemin, Magid M. Abraham, Jay D. Amsterdam, Ian M. Anderson, Chittaranjan Andrade, Glen B. Baker, Aartjan T.F. Beekman, Michael Berk, Tom K. Birkenhäger, Barry B. Blackwell, Pierre Blier, Marc B.J. Blom, Alexander J. Bodkin, Carlo I. Cattaneo, Bezalel Dantz, Jonathan Davidson, Boadie W. Dunlop, Ryan F. Estévez, Shalom S. Feinberg, John P.M. Finberg, Laura J. Fochtmann, David Gotlib, Andrew Holt, Thomas R. Insel, Jens K. Larsen, Rajnish Mago, David B. Menkes, Jonathan M. Meyer, David J. Nutt, Gordon Parker, Mark D. Rego, Elliott Richelson, Henricus G. Ruhé, Jerónimo Sáiz-Ruiz, Stephen M. Stahl, Thomas Steele, Michael E. Thase, Sven Ulrich, Anton J.L.M. van Balkom, Eduard Vieta, Ian Whyte, Allan H. Young, Peter K. Gillman
-
- Journal:
- CNS Spectrums / Volume 28 / Issue 4 / August 2023
- Published online by Cambridge University Press:
- 15 July 2022, pp. 427-440
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
This article is a clinical guide which discusses the “state-of-the-art” usage of the classic monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice. The guide is for all clinicians, including those who may not be experienced MAOI prescribers. It discusses indications, drug-drug interactions, side-effect management, and the safety of various augmentation strategies. There is a clear and broad consensus (more than 70 international expert endorsers), based on 6 decades of experience, for the recommendations herein exposited. They are based on empirical evidence and expert opinion—this guide is presented as a new specialist-consensus standard. The guide provides practical clinical advice, and is the basis for the rational use of these drugs, particularly because it improves and updates knowledge, and corrects the various misconceptions that have hitherto been prominent in the literature, partly due to insufficient knowledge of pharmacology. The guide suggests that MAOIs should always be considered in cases of treatment-resistant depression (including those melancholic in nature), and prior to electroconvulsive therapy—while taking into account of patient preference. In selected cases, they may be considered earlier in the treatment algorithm than has previously been customary, and should not be regarded as drugs of last resort; they may prove decisively effective when many other treatments have failed. The guide clarifies key points on the concomitant use of incorrectly proscribed drugs such as methylphenidate and some tricyclic antidepressants. It also illustrates the straightforward “bridging” methods that may be used to transition simply and safely from other antidepressants to MAOIs.
Preface
- Homer
- Edited by Irene J. F. de Jong, Universiteit van Amsterdam
-
- Book:
- Homer: Iliad Book 22
- Published online:
- 05 June 2012
- Print publication:
- 12 January 2012, pp vii-viii
-
- Chapter
- Export citation
-
Summary
Some thirty years ago I applied for a grant to write a thesis that would consist of a commentary on Iliad 22. I was not awarded the grant and when a rumour started to spread that a team under the supervision of Geoffrey Kirk was preparing a commentary on the whole Iliad I turned my attention to another topic, the application of narratology to Homer. Given this history, it was with great joy that I accepted the invitation of the series editors Pat Easterling and Richard Hunter to write a ‘Green and Yellow’ on this very book.
I have focused on two aspects in this commentary: Homer’s language (especially his oral syntax, the meaning of words, and the function of particles) and narrative style (for instance the structure of scenes, the relationship of narrator and characters, and the directing of the narratees’ emotional response). Much important work has been done in the field of the language of the Homeric epics in the last decades. Thus, the invaluable Lexikon des frühgriechischen Epos was finally completed in 2010, and this treasure-trove of information deserves to be introduced more fully into English-speaking Homeric scholarship. I feel a special attachment to this formidable instrument because I spent a very pleasant and formative year as stipendiary in Hamburg, working on lemmata like θέλγω and ἰσόθɛος. Our understanding of Greek particles has advanced greatly since the publication of Denniston’s standard text, not least, if some chauvinism is allowed, thanks to the work of Dutch scholars on τɛ, πɛρ, μήν, δή, and ἄρα. Finally, the insight has dawned that we should approach the oral syntax of Homer somewhat differently from that of later, written texts. It is a flow through time rather than a structure on the space of a page, and keeping this principle in mind can help us to appreciate and better understand the construction of his sentences.
![](/core/cambridge-core/public/images/lazy-loader.gif)