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Stagsden and its Manors
- William Austin, Jannion Steele Elliott, G. Herbert Fowler, Hilary Jenkinson, Frederic Augustus Page-Turner
- Edited by Joseph Hight Blundell, C. W. Foster, Fred. Puttnam, Robert Richmond
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- Book:
- The Publications of the Bedfordshire Historical Record Society
- Published by:
- Boydell & Brewer
- Published online:
- 18 July 2023, pp 1-14
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Summary
The particulars given in the holders of Stagsden lands the Domesday Survey of are as follows :—
With but this sparse information and other factors to be brought forward, it is not difficult at least to surmise the whereabouts of such respective holdings, if not conclusively to locate the precise boundaries.
Hugh de Beauchamp, the all important Baron of Bedford held the only land which is recorded as a Manor in Stagsden, of which two hides, it is stated, were held in demesne. This was a Manor not only of considerable importance, but of special interest, as it is the only instance in Domesday relating to any part of Bedfordshire wherein it is recorded “ There is a park for woodland beasts” (parchus ferarum silvaticarum). The location of such manorial demesne was, as will subsequently be proved, in the southern portion of the parish; and with other lands was continued to the north-eastern boundary.
The one hide held by Countess Judith was probably adjoining the above on the eastern side of the parish. The Countess held the whole of Kempston, as also 2 hides of land in the adjoining parish of Bromham; the latter included Buelles or Bowels Manor (the site of its Manor House appears previously to have been unrecorded) and she also held a mill. It seems reasonable to assume that her land in Stagsden would march with that in the adjoining parishes; and that portion of land which is divided off from the other part of the parish by the Bedford to Newport highway and the first connecting road to Kempston, at once suggests itself both as to area and placement, unless we have some rebutting evidence for the contrary. Further, the amount of woodland required for the pannage of swine, in proportion to the hidage belonging to the Countess, infers that her land was considerably wooded, which this part of the parish is even to the present day; and there is no evidence of any other part of Stagsden (at least as far back as the 13th century) ever being so much under woodland. Subsequently the land of the Countess Judith, whose sub-holder was Hugh de Beauchamp, became absorbed into other lands held by him in the parish, and no further mention of it as a separate estate appears to be traceable.
Associations of negative affective biases and depressive symptoms in a community-based sample
- Laura de Nooij, Mark J. Adams, Emma L. Hawkins, Liana Romaniuk, Marcus R. Munafò, Ian S. Penton-Voak, Rebecca Elliott, Amy R. Bland, Gordon D. Waiter, Anca-Larisa Sandu, Tina Habota, J. Douglas Steele, Alison D. Murray, Archie Campbell, David J. Porteous, Generation Scotland, Andrew M. McIntosh, Heather C. Whalley
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- Journal:
- Psychological Medicine / Volume 53 / Issue 12 / September 2023
- Published online by Cambridge University Press:
- 21 September 2022, pp. 5518-5527
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Background
Major depressive disorder (MDD) was previously associated with negative affective biases. Evidence from larger population-based studies, however, is lacking, including whether biases normalise with remission. We investigated associations between affective bias measures and depressive symptom severity across a large community-based sample, followed by examining differences between remitted individuals and controls.
MethodsParticipants from Generation Scotland (N = 1109) completed the: (i) Bristol Emotion Recognition Task (BERT), (ii) Face Affective Go/No-go (FAGN), and (iii) Cambridge Gambling Task (CGT). Individuals were classified as MDD-current (n = 43), MDD-remitted (n = 282), or controls (n = 784). Analyses included using affective bias summary measures (primary analyses), followed by detailed emotion/condition analyses of BERT and FAGN (secondary analyses).
ResultsFor summary measures, the only significant finding was an association between greater symptoms and lower risk adjustment for CGT across the sample (individuals with greater symptoms were less likely to bet more, despite increasingly favourable conditions). This was no longer significant when controlling for non-affective cognition. No differences were found for remitted-MDD v. controls. Detailed analysis of BERT and FAGN indicated subtle negative biases across multiple measures of affective cognition with increasing symptom severity, that were independent of non-effective cognition [e.g. greater tendency to rate faces as angry (BERT), and lower accuracy for happy/neutral conditions (FAGN)]. Results for remitted-MDD were inconsistent.
ConclusionsThis suggests the presence of subtle negative affective biases at the level of emotion/condition in association with depressive symptoms across the sample, over and above those accounted for by non-affective cognition, with no evidence for affective biases in remitted individuals.
The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression
- Vincent Van den Eynde, Wegdan R. Abdelmoemin, Magid M. Abraham, Jay D. Amsterdam, Ian M. Anderson, Chittaranjan Andrade, Glen B. Baker, Aartjan T.F. Beekman, Michael Berk, Tom K. Birkenhäger, Barry B. Blackwell, Pierre Blier, Marc B.J. Blom, Alexander J. Bodkin, Carlo I. Cattaneo, Bezalel Dantz, Jonathan Davidson, Boadie W. Dunlop, Ryan F. Estévez, Shalom S. Feinberg, John P.M. Finberg, Laura J. Fochtmann, David Gotlib, Andrew Holt, Thomas R. Insel, Jens K. Larsen, Rajnish Mago, David B. Menkes, Jonathan M. Meyer, David J. Nutt, Gordon Parker, Mark D. Rego, Elliott Richelson, Henricus G. Ruhé, Jerónimo Sáiz-Ruiz, Stephen M. Stahl, Thomas Steele, Michael E. Thase, Sven Ulrich, Anton J.L.M. van Balkom, Eduard Vieta, Ian Whyte, Allan H. Young, Peter K. Gillman
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- Journal:
- CNS Spectrums / Volume 28 / Issue 4 / August 2023
- Published online by Cambridge University Press:
- 15 July 2022, pp. 427-440
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This article is a clinical guide which discusses the “state-of-the-art” usage of the classic monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice. The guide is for all clinicians, including those who may not be experienced MAOI prescribers. It discusses indications, drug-drug interactions, side-effect management, and the safety of various augmentation strategies. There is a clear and broad consensus (more than 70 international expert endorsers), based on 6 decades of experience, for the recommendations herein exposited. They are based on empirical evidence and expert opinion—this guide is presented as a new specialist-consensus standard. The guide provides practical clinical advice, and is the basis for the rational use of these drugs, particularly because it improves and updates knowledge, and corrects the various misconceptions that have hitherto been prominent in the literature, partly due to insufficient knowledge of pharmacology. The guide suggests that MAOIs should always be considered in cases of treatment-resistant depression (including those melancholic in nature), and prior to electroconvulsive therapy—while taking into account of patient preference. In selected cases, they may be considered earlier in the treatment algorithm than has previously been customary, and should not be regarded as drugs of last resort; they may prove decisively effective when many other treatments have failed. The guide clarifies key points on the concomitant use of incorrectly proscribed drugs such as methylphenidate and some tricyclic antidepressants. It also illustrates the straightforward “bridging” methods that may be used to transition simply and safely from other antidepressants to MAOIs.