In 1898 Arloing and Courmont published the results of experiments made by them on the agglutination produced by the serum of tubercular patients. For this purpose they used a strain of the tubercle bacillus isolated by the former, which produced a uniform turbidity when grown in glycerine broth. With this culture, serum from tubercular patients gave reactions at dilutions of 1 in 5, 10 or 20 in a large percentage of cases, and that from normal individuals only in a much smaller percentage and then not very strongly. From this they concluded that the agglutination reaction was likely to be of considerable use in the diagnosis of tuberculosis.