Increases in height were reported in children chronically exposed prenatally and postnatally to D2
receptor-blocking drugs. A possible haplotypic association between stature and the DRD2 gene was
also reported. In this study, we examined linkage between stature and DRD2 by genotyping a
dinucleotide repeat polymorphism in 79 sib-pairs aged 8–17 years. An association between stature
and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in
the sib-pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage (p = 0.004,
SIBPAL) and an association (p = 0.009, paired t-test, in the sib-pairs; p = 0.006, ANOVA, in the
adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that
contribute to heritability of stature.