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The Feasibility of Creating a Population-Based National Twin Registry in the United States
- Patricia C. Chulada, Linda A. Corey, Vani Vannappagari, Nedra S. Whitehead, Perry J. Blackshear
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- Journal:
- Twin Research and Human Genetics / Volume 9 / Issue 6 / 01 December 2006
- Published online by Cambridge University Press:
- 21 February 2012, pp. 919-926
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Between 4 to 6 million twins exist in the US today who offer scientists a valuable potential resource for conducting behavioral and biomedical research. However, unlike many other countries, there is no national system in the US for identifying twins and eliciting their participation in these important research programs. Therefore, the National Institute of Environmental Health Sciences (NIEHS) is conducting a study to determine the feasibility of creating a national, population-based twin registry in the US. The major goal is to estimate the potential size and characteristics of a national twin registry based on the current twin population in the US, our ability to ascertain and enrol them, and their willingness to participate. Existing US twin cohorts are also being examined in this study as well as alternatives for improving US twin resources should a national twin registry be deemed infeasible. The various options will be compared in terms of possible source populations, generalizability and adequacy for statistically powering various types of etiological studies. Two expert advisory panels have been assembled to assist in the conduct of this study. The Scientific Advisory Panel is charged with providing expertise concerning study goals, design and methodology, and evaluating the study's conclusion. A separate Ethics Advisory Panel is charged with providing expertise on the ethical, legal, and social issues that might be encountered if a national twin registry is ultimately pursued. Having a national population-based twin registry in the US would be advantageous to US scientists and those worldwide. It would provide ample numbers of twin pairs to conduct various types of environmental genomic studies currently not possible with existing US twin resources. It would also allow US scientists to select for characteristics (race, ethnicity, environments, and so on) inherent in our own population. Finally and foremost, it would help to meet the worldwide demand for twin resources which is expected to increase over time, as new genomic and analytical tools become available and new hypotheses emerge concerning the complex interplay between genes, lifestyles and environment.
Contributors
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- By Jane E. Adcock, Yahya Aghakhani, A. Anand, Eva Andermann, Frederick Andermann, Alexis Arzimanoglou, Sandrine Aubert, Nadia Bahi-Buisson, Carman Barba, Agatino Battaglia, Geneviève Bernard, Nadir E. Bharucha, Laurence A. Bindoff, William Bingaman, Francesca Bisulli, Thomas P. Bleck, Stewart G. Boyd, Andreas Brunklaus, Harry Bulstrode, Jorge G. Burneo, Laura Canafoglia, Laura Cantonetti, Roberto H. Caraballo, Fernando Cendes, Kevin E. Chapman, Patrick Chauvel, Richard F. M. Chin, H. T. Chong, Fahmida A. Chowdhury, Catherine J. Chu-Shore, Rolando Cimaz, Andrew J. Cole, Bernard Dan, Geoffrey Dean, Alessio De Ciantis, Fernando De Paolis, Rolando F. Del Maestro, Irissa M. Devine, Carlo Di Bonaventura, Concezio Di Rocco, Henry B. Dinsdale, Maria Alice Donati, François Dubeau, Michael Duchowny, Olivier Dulac, Monika Eisermann, Brent Elliott, Bernt A. Engelsen, Kevin Farrell, Natalio Fejerman, Rosalie E. Ferner, Silvana Franceschetti, Robert Friedlander, Antonio Gambardella, Hector H. Garcia, Serena Gasperini, Lorenzo Genitori, Gioia Gioi, Flavio Giordano, Leif Gjerstad, Daniel G. Glaze, Howard P. Goodkin, Sidney M. Gospe, Andrea Grassi, William P. Gray, Renzo Guerrini, Marie-Christine Guiot, William Harkness, Andrew G. Herzog, Linda Huh, Margaret J. Jackson, Thomas S. Jacques, Anna C. Jansen, Sigmund Jenssen, Michael R. Johnson, Dorothy Jones-Davis, Reetta Kälviäinen, Peter W. Kaplan, John F. Kerrigan, Autumn Marie Klein, Matthias Koepp, Edwin H. Kolodny, Kandan Kulandaivel, Ruben I. Kuzniecky, Ahmed Lary, Yolanda Lau, Anna-Elina Lehesjoki, Maria K. Lehtinen, Holger Lerche, Michael P. T. Lunn, Snezana Maljevic, Mark R. Manford, Carla Marini, Bindu Menon, Giulia Milioli, Eli M. Mizrahi, Manish Modi, Márcia Elisabete Morita, Manuel Murie-Fernandez, Vivek Nambiar, Lina Nashef, Vincent Navarro, Aidan Neligan, Ruth E. Nemire, Charles R. J. C. Newton, John O'Donavan, Hirokazu Oguni, Teiichi Onuma, Andre Palmini, Eleni Panagiotakaki, Pasquale Parisi, Elena Parrini, Liborio Parrino, Ignacio Pascual-Castroviejo, M. Scott Perry, Perrine Plouin, Charles E. Polkey, Suresh S. Pujar, Karthik Rajasekaran, R. Eugene Ramsey, Rahul Rathakrishnan, Roberta H. Raven, Guy M. Rémillard, David Rosenblatt, M. Elizabeth Ross, Abdulrahman Sabbagh, P. Satishchandra, Swati Sathe, Ingrid E. Scheffer, Philip A. Schwartzkroin, Rod C. Scott, Frédéric Sedel, Michelle J. Shapiro, Elliott H. Sherr, Michael Shevell, Simon D. Shorvon, Adrian M. Siegel, Gagandeep Singh, S. Sinha, Barbara Spacca, Waney Squier, Carl E. Stafstrom, Bernhard J. Steinhoff, Andrea Taddio, Gianpiero Tamburrini, C. T. Tan, Raymond Y. L. Tan, Erik Taubøll, Robert W. Teasell, Mario Giovanni Terzano, Federica Teutonico, Suzanne A. Tharin, Elizabeth A. Thiele, Pierre Thomas, Paolo Tinuper, Dorothée Kasteleijn-Nolst Trenité, Sumeet Vadera, Pierangelo Veggiotti, Jean-Pierre Vignal, J. M. Walshe, Elizabeth J. Waterhouse, David Watkins, Ruth E. Williams, Yue-Hua Zhang, Benjamin Zifkin, Sameer M. Zuberi
- Edited by Simon D. Shorvon, Frederick Andermann, Renzo Guerrini
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- Book:
- The Causes of Epilepsy
- Published online:
- 05 March 2012
- Print publication:
- 14 April 2011, pp ix-xvi
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Contributors
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- By Farook Al-Azzawi, Wita Angrianni, Sanjay Asthana, Stephan Bandelow, Kathryn J. Bryan, Cynthia M. Carlsson, Jenna C. Carroll, Gemma Casadesus, Monique M. Cherrier, Laura H. Coker, María M. Corrada, Vita Priantina Dewi, Roberta Diaz Brinton, Mark A. Espeland, Mirjam I. Geerlings, Robert B. Gibbs, Carey E. Gleason, Victor W. Henderson, Patricia E. Hogan, Eef Hogervorst, Claudia H. Kawas, Anna Khaylis, Philip Kreager, Linda Kushandy, Donald Lehmann, Jin Li, Mary E. McAsey, Pauline M. Maki, Ralph N. Martins, Scott D. Moffat, Majon Muller, Theresia Ninuk, Annlia Paganini-Hill, George Perry, Christian J. Pike, Bevin N. Powers, Tri Budi W. Rahardjo, Natalie L. Rasgon, Susan M. Resnick, Emily R. Rosario, Sabarinah, Tony Sadjimim, Barbara B. Sherwin, Sally A. Shumaker, Mark A. Smith, Robert G. Struble, Chris Talbot, Wulf H. Utian, Giuseppe Verdile, Robert B. Wallace, Whitney Wharton, Katherine E. Williams, Oliver T. Wolf, Tonita E. Wroolie, Amina Yesufu, Yudarini, Liqin Zhao
- Edited by Eef Hogervorst, Loughborough University, Victor W. Henderson, Stanford University, California, Robert B. Gibbs, University of Pittsburgh, Roberta Diaz Brinton, University of Southern California
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- Book:
- Hormones, Cognition and Dementia
- Published online:
- 06 July 2010
- Print publication:
- 24 September 2009, pp vii-x
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Reassessing the Traditional Interpretation of “Manioc” Artifacts in the Orinoco Valley of Venezuela
- Linda Perry
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- Journal:
- Latin American Antiquity / Volume 16 / Issue 4 / December 2005
- Published online by Cambridge University Press:
- 20 January 2017, pp. 409-426
- Print publication:
- December 2005
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There exists general consensus in the archaeological literature that bitter manioc was a staple crop in precontact agricultural systems in the lowlands of South America. This view is based upon the indirect evidence derived from archaeological ceramic and lithic assemblages rather than archaeobotanical evidence, the preserved remains of bitter manioc itself. Studies of microlithic “manioc” grater flakes from Pozo Azul Norte-1, a site located in the middle Orinoco valley of Venezuela, reveal a much more complex function of these artifacts involving the processing of several starchy roots including arrowroot, guapo, yam, and ginger, as well as seeds including maize and possibly palm. The starch and use-wear data collected in these investigations indicate that archaeobotanical data are a more reliable means of assessing the function of these tools than are ethnographic analogues.
14 - Traditions in wild white-faced capuchin monkeys
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- By Susan Perry, Assistant Professor in the Department of Anthropology, University of California, Los Angeles, Melissa Panger, Department of Anthropology, George Washington University, 2110 G St. NW, Washington, DC 20052, USA, Lisa M. Rose, Department of Anthropology and Sociology, University of British Columbia. 6303 NW Marine Drive, Vancouver, British Columbia, V6T, Mary Baker, Department of Anthropology, Whittier College, 13406 Philadelphia St., Whittier, CA 90608, USA, Julie Gros-Louis, Department of Psychology, University of Indiana, 1101 E. 10th St., Bloomington, IN 47405, USA, Katherine Jack, Department of Anthropology, Appalachian State University, Boone, NC 28608, USA, Katherine C. Mackinnon, Department of Sociology and Criminal Justice, Saint Louis University, 3500 Lindell Boulevard, St. Louis, MO 63103, USA, Joseph Manson, Max-Planck-Institut für evolutionäre Anthropologie, Inselstraße 22, 04103 Leipzig, Germany, Linda Fedigan, Department of Anthropology, University of Calgary, Calgary, Alberta T2N 1N4, Canada, Kendra Pyle, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
- Edited by Dorothy M. Fragaszy, University of Georgia, Susan Perry, University of California, Los Angeles
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- Book:
- The Biology of Traditions
- Published online:
- 27 October 2009
- Print publication:
- 03 July 2003, pp 391-425
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Summary
Introduction
Primatologists have long recognized that social learning could play an important role in food choice and food processing in primates, since the discovery (by Itani in 1958) of innovative food-processing techniques disseminated among Japanese macaques (see Ch. 10 for a review of subsequent findings). It is somewhat surprising that, after the initial discovery of the importance of social learning in Japanese macaques, practically all subsequent research on social learning in wild nonhuman primates has been on apes (e.g. Boesch, 1996a, 1996b; Boesch and Boesch-Achermann, 2000; Boesch and Tomasello, 1998; McGrew, 1992, 1998; van Schaik, Deaner, and Merrill, 1999; Whiten et al., 1999; see Chs. 10 and 11). To remedy the gap in what we know about social learning in natural settings in other primates, and because a truly comparative framework is necessary to understand the biological underpinnings of social learning (see Ch. 1), we began a comprehensive study of social learning in wild capuchin monkeys (Cebus spp.). Our study investigates the probable role of social learning in a number of behavioral domains.
Capuchins seem particularly likely to exhibit extensive reliance on learning, and social learning in particular, for the following reasons (Fragaszy, Visalberghi, and Fedigan, 2003). Several aspects of capuchin ecology promote behavioral flexibility. First, the genus Cebus occupies a wider geographic area than any other New World genus apart from Alouatta (Emmons, 1997), and it uses many different habitat types. Therefore, capuchins face a wide variety of environmental challenges.
Intravenous Tubing Containing Burettes Can Be Safely Changed at 72 Hour Intervals
- David R. Snydman, Maureen Donnelly-Reidy, Linda K. Perry, William J. Martin
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- Journal:
- Infection Control / Volume 8 / Issue 3 / March 1987
- Published online by Cambridge University Press:
- 02 January 2015, pp. 113-116
- Print publication:
- March 1987
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No studies testing the safety of changing intravenous systems containing in-line burettes at 72 hours in an intensive care setting have been performed. Patients entering a medical or surgical intensive care unit were alternatively assigned to have any line with an in-line burette changed at either 48 hour (105 patients) or 72 hour (65 patients) intervals. Daily quantitative cultures with a 2 ml aliquot of burette fluid were obtained. Contaminated burette fluid was detected in 60 of 1181 (5.0%, 95% confidence interval, 3.7% to 6.3%) samples from the burettes changed at 48 hour intervals, and in 40 of 901 (4.4%, 95% confidence interval, 3.0% to 5.8%) samples from 72 hour interval burettes. Significant bacterial contamination of burette fluid, defined as ten or more colonies per milliliter, occurred in only seven (0.6%) cultures from patients in the 48 hour interval group compared with only three (0.3%) cultures in the 72 hour group. None of the contaminated burette fluids was associated with a primary bacteremia. Change of inline burettes in patients in intensive care at 72-hour intervals is safe and should result in substantial cost savings to hospitals.
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