Note: This article summarizes the result of a part of the author's research in the economic history of the Serbian lands and the Republic of Ragusa (Dubrovnik). The work was begun in Yugoslavia in 1938 and then continued, with interruptions, in England and the United States. It is the special aim of the author to investigate documents and reconstruct the commercial history of Ragusa during the period of the Commercial Revolution, principally the sixteenth and seventeenth centuries, in connection with the discoveries and the colonization of America. It is almost unknown that Ragusa was one of the principal commercial and naval powers in the period 1510–1667 and that it played an important role in the history of Brazil, the Caribbean, and the West Indies in general. The same goes for England, the Netherlands, Spain, and other regions. The author will center his work around three regions in which the role of Ragusan commerce and navigation was of extreme importance: (a) Spain and America, (b) England and the Netherlands, and (c) the Levant and the East Indies.