The biology and biogeography of the economically important species of Heteropsylla Crawford, including H. cubana Crawford, are discussed. Heteropsylla comprises a group of legume-feeding neotropical psyllids within the subfamily Ciriacreminae. Taxonomic characteristics previously used to diagnose Heteropsylla and related genera are discussed and a new generic diagnosis is made using both adult and larval characters. Thirty-nine species of Heteropsylla are now recognized and each is described and illustrated. Of these, 21 are new to science. One species, H. boquetensis (Brown & Hodkinson), is transferred from Limbopsylla Brown & Hodkinson. Final instar larvae of 22 species are described and illustrated. Host-plants are recorded for 35 species, showing that Heteropsylla species are generally found on legumes belonging to the Mimosoideae. Three exceptions occur in the Caesalpinioideae. A checklist of species and keys to the identification of adult males, adult females and final instar larvae are provided.