We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Objectives/Goals: Team science (TS) competency is important for translational science team collaboration. However, there are few educators available to assist teams. Asynchronous learning is an effective strategy for delivering TS content. The goal of this project is to expand TS education by providing online access to our learners using online modules. Methods/Study Population: The Collaboration and Team Science (CaTS) team at the University of Cincinnati provides a robust TS education and training program. As the need for team science gains recognition, CaTS has received increased requests for services, leading to a need to broaden TS offerings. To address this demand, the CaTS team created “Team Science 101,” an online, asynchronous, series of 15 modules covering basic team science concepts. Each module consists of an educational recording lasting an average of 20 minutes, optional topic resources, pre- and post-module surveys assessing learners’ confidence and satisfaction, post-module knowledge checks, and evaluation questions. Upon completing all modules, participants receive a completion certificate. Results/Anticipated Results: TS 101 will be piloted with a group of participants who expressed interest in asynchronous TS content and will be adjusted based on the feedback received. The associated pre- and post-module survey, post-module knowledge check, and evaluation questions will be monitored to determine learning levels and improve TS 101 overall. Canvas is the educational platform that houses these modules, allowing for participant follow-up and scalable dissemination. The CaTS team plans to disseminate TS 101 nationally and internationally for anyone interested in this resource. Discussion/Significance of Impact: There is a national effort to collect and curate TS education, training, and toolkits. TS 101 will be a useful educational tool that will expand the reach of team science educators, provide the foundation for educators to explore topics more deeply by building on the module topics, and provide education to broader audiences who lack access to TS experts.
Patients with hematological malignancies are at high risk of infections due to both the disease and the associated treatments. The use of immunoglobulin (Ig) to prevent infections is increasing in this population, but its cost effectiveness is unknown. This trial-based economic evaluation aimed to compare the cost effectiveness of prophylactic Ig with prophylactic antibiotics in patients with hematological malignancies.
Methods
The economic evaluation used individual patient data from the RATIONAL feasibility trial, which randomly assigned 63 adults with chronic lymphocytic leukemia, multiple myeloma, or lymphoma to prophylactic Ig or prophylactic antibiotics. The following two analyses were conducted to estimate the cost effectiveness of the two treatments over the 12-month trial period from the perspective of the Australian health system:
(i) a cost-utility analysis (CUA) to assess the incremental cost per quality-adjusted life-year (QALY) gained using data collected with the EuroQol 5D-5L questionnaire; and
(ii) a cost-effectiveness analysis (CEA) to assess the incremental cost per serious infection prevented (grade ≥3) and per infection prevented (any grade).
Results
The total cost per patient was significantly higher in the Ig arm than in the antibiotic arm (difference AUD29,140 [USD19,000]). There were non-significant differences in health outcomes between the treatment arms: patients treated with Ig had fewer QALYs (difference −0.072) and serious infections (difference −0.26) than those given antibiotics, but more overall infections (difference 0.76). The incremental cost-effectiveness from the CUA indicated that Ig was more costly than antibiotics and associated with fewer QALYs. In the CEA, Ig costed an additional AUD111,262 (USD73,000) per serious infection prevented, but it was more costly than antibiotics and associated with more infections when all infections were included.
Conclusions
These results indicate that, on average, Ig prophylactic treatment may not be cost effective compared with prophylactic antibiotics for the group of patients with hematological malignancies recruited to the RATIONAL feasibility trial. Further research is needed to confirm these findings in a larger population and over the longer term.
This chapter analyses the Tasmanian Journal of Natural Science (1841–1849), the first Australian scientific periodical. Although Lieutenant-Governor John Franklin was the journal’s patron, Jane Franklin used the Tasmanian Journal to pursue her interests in botanical science, domestic experiments with Indigenous children and educational reform. The Tasmanian Journal was a material record of the Franklins’ efforts to use science and education to change colonial culture. It reveals the scientific endeavours undertaken by local collectors and visiting scientists, and provides an insight into the scissors-and-paste construction of periodical publications. Notable contributors included the scientist and explorer Paul Strzelecki, the New Zealand missionary botanist William Colenso, the ornithologist John Gould and Dr Edmund Hobson who studied the platypus and, with his wife Margaret, identified marsupial megafauna fossils. Local collectors used science to further their social status, and local elites used scientific print culture to further their political and intellectual interests. Colonial and imperial politics intersected with scientific print culture, in which race, gender and knowledge played complicated roles. Alongside the scientific journal, colonial newspapers and Indigenous letter writers and petitioners from Flinders Island used Tasmania’s distinctive print culture to raise pressing questions about colonial governance, Indigenous welfare and the settler colonial public sphere.
The penal colonies were modern experiments that attempted to resolve surplus British populations, achieve strategic and naval ambitions, and form new imperial markets. Metropolitan reformers were keenly interested in prison systems, writing speculative accounts and plans in response to early evidence from New South Wales. This chapter analyses major theories about the penal colonies and ‘systematic colonization’ by Jeremy Bentham and Edward Gibbon Wakefield, examining how evidence was drawn from colonial texts and repurposed for metropolitan interests. Alternative forms of information from the colonies were fed into metropolitan inquiries by the Quaker travellers James Backhouse and George Washington Walker. Quasi-official colonial experiments with convicts and prison reform trialled through the first half of the nineteenth century in many cases anticipated the prison reform underway in Britain. This chapter analyses the network of texts that brought metropolitan attention to bear on controversial aspects of convict transportation and colonial reform that reshaped ideas about society, crime, and punishment, with distinctive religious overtones, and how new models for reform emerged from colonial experiments.
The introduction showcases colonial officials, missionaries and natural history collectors who, alongside Indigenous interlocutors and metropolitan advocates, sought to collect and use Antipodean information. Three key fields of knowledge emerged from the Australian colonies, and they reveal the relationship between knowledge formation and print culture. Part 1, Imagining Settler Humanitarianism, examines key debates about convictism, race and morality. Part 2, Regulating Settler Society, focuses on convictism and the forms of knowledge about reforming the self and regulating society that emerged from penal experiments. Part 3, Inventing Settler Science, shows how the scientific novelty of the Australian colonies attracted attention from the Endeavour voyage onwards, and inaugurated networks of correspondence, collection and publication that struggled to account for the Indigenous knowledge and participation that characterised the colonies.
This chapter examines eighteenth-century textual records about the Australian colonies, from the early British press reports of the establishment of the penal colony at Port Jackson to the accounts of religious personnel such as the first colonial chaplain Richard Johnson. It reveals how convicts and Indigenous people were represented in texts designed for metropolitan audiences. The isolated voices of evangelical reformers provided rich accounts of the problems and failures of the penal colony. They questioned the morality of the military governance of the penal colony and the dispossession of Indigenous peoples. Evangelical accounts from New South Wales became part of a global knowledge economy and a thriving print culture; they provided evidence that thickened, and at times contradicted, official accounts that circulated in the British media.
The conclusion draws together the threads of the three key fields of colonial knowledge and shows some of the later trajectories of these rich archives. Australian data proved central to key ideas that were fomented during the nineteenth century, and which continue to affect contemporary society. Debates about civilisational orders, and about the role of science and religion in relation to the extension of imperial power and economic privilege, were widespread. The distinctive nature of the Australian colonial experiment continues to make important contributions to global debates about the history of humanitarianism and human rights, apologies and reparations sought by colonised and displaced peoples for the wrongs of imperialism and colonial governance, and the uneven distribution of wealth, up to the twenty-first century.
This chapter analyses colonial botanical collection to reveal the role of non-elite collectors and Indigenous interlocutors in providing knowledge that underpinned British science. The Endeavour brought the new taxonomy of Carl Linnaeus to the Southern Hemisphere. Joseph Banks, Daniel Solander and Sydney Parkinson recorded findings and took over 30,000 plants back to London, many of them viewed for the first time by Europeans swept up in the rage for botany. Knowledge production after James Cook’s first voyage was exponential, and it had both scientific and territorial consequences. New kinds of scientific writing also emerged from the controversial publication of Parkinson’s journal, and scientific bodies used innovative magazines to broaden access to and public support of science in the service of empire. Reliable collectors in the settler colonies worked with Indigenous collaborators to identify novel plant and animal materials, and send them to Britain. These included George Caley who worked with the Eora youth Daniel Moowaatin. The history of colonial science was informed by diverse participants, interests and motivations, and it changed how field work was conceived and scientific authority was established.
This chapter examines linguistic studies to explore colonial knowledge production as a shared, cross-cultural process between Indigenous people and European interlocutors. Colonial officials learnt languages from trusted individuals, such as the surveyor and astronomer William Dawes and the Indigenous woman Patyegarang in the 1790s. Nineteenth-century linguistic collection was undertaken by amateur settlers with a variety of intentions. Collected on the frontier, and often in the midst of massacre and violent dispossession, wordlists, songs and grammars contain evidence of traditional Indigenous knowledge as it was translated and transcribed into new forms. The Revd Lancelot Threlkeld’s Awabakal language collaborations with Biraban from the 1820s were circulated to imperial exhibitions and Sir George Grey’s library in Cape Town. Indigenous languages enabled Eliza Hamilton Dunlop to write poetry on Indigenous themes in New South Wales in the 1840s that publicised settler violence and massacres. Harriott Barlow’s language records of southwest Queensland were published by the Royal Anthropological Institute of Great Britain in 1873. Distributed, published and consumed far from their frontier sites of collection, linguistic studies from the Australian colonies were influential in major world theories of language, race and culture.