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137 results

Page 1 of 7

  • P.011 Efficacy and safety of ravulizumab in adults with AQP4+ NMOSD: interim analysis from the ongoing phase 3 CHAMPION-NMOSD trial

  • SJ Pittock, M Barnett, JL Bennett, A Berthele, J de Sèze, M Levy, I Nakashima, C Oreja-Guevara, J Palace, F Paul, C Pozzilli, Y Mashhoon, K Allen, B Parks, H Kim, G Vorobeychik
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 51 / Issue s1 / June 2024
    Published online by Cambridge University Press:
    24 May 2024, p. S17
    • Article
      • You have access
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  • Background: CHAMPION-NMOSD (NCT04201262) is an ongoing global, open-label, phase 3 study evaluating ravulizumab in AQP4+ NMOSD. Methods: Adult patients received an intravenous, weight-based loading dose of ravulizumab on day 1 and a maintenance dose on day 15 and every 8 weeks thereafter. Following a primary treatment period (PTP; up to 2.5 years), patients could enter a long-term extension (LTE). Results: 58 patients completed the PTP; 56/2 entered/completed the LTE. As of June 16, 2023, median (range) follow-up was 138.4 (11.0-183.1) weeks for ravulizumab (n=58), with 153.9 patient-years. Across the PTP and LTE, no patients had an adjudicated on-trial relapse during ravulizumab treatment. 91.4% (53/58 patients) had stable or improved Hauser Ambulation Index score. 91.4% (53/58 patients) had no clinically important worsening in Expanded Disability Status Scale score. The incidence of treatment-emergent adverse events (TEAEs) and serious adverse events was 94.8% and 25.9%, respectively. Most TEAEs were mild to moderate in severity and unrelated to ravulizumab. TEAEs leading to withdrawal from ravulizumab occurred in 1 patient. Conclusions: Ravulizumab demonstrated long-term clinical benefit in the prevention of relapses in AQP4+ NMOSD with a safety profile consistent with prior analyses.

Applied Quantum Mechanics
  • 3rd edition
  • A. F. J. Levi
  • Published online:
    27 October 2023
    Print publication:
    31 August 2023
  • Featuring new coverage of quantum engineering and quantum information processing, the third edition of this bestselling textbook continues to provide a uniquely practical introduction to the fundamentals of quantum mechanics. It features straightforward explanations of quantum effects, suitable for readers from all backgrounds; real-world engineering problems showcasing the practical application of theory to practice, providing a relevant and accessible introduction to cutting-edge quantum applications; over 60 accessible worked examples using MATLAB (as well as open-source Python), allowing deepened understanding through computational exploration and visualization; and a new chapter on quantum engineering, introducing state-of-the-art concepts in quantum information processing and quantum device design. Updated throughout and supported online by downloadable MATLAB code, exam questions, and solutions to over 150 homework problems for instructors, this is the ideal textbook for senior undergraduate and graduate students in applied science, applied physics, engineering, and materials science studying a first course in quantum mechanics.

  • 3 - Electron Propagation

  • A. F. J. Levi, University of Southern California
  • Book:
    Applied Quantum Mechanics
    Published online:
    27 October 2023
    Print publication:
    31 August 2023, pp 105-169

  • Summary

    The propagation method can be used to describe a particle with wave character moving in an arbitrary one-dimensional potential, V(x). This is done by approximating the potential as a series of potential steps. For a particle of energy E incident from the left, transmission and reflection at the first step is calculated along with phase accumulated propagating to the step and expressed as a 2×2 matrix.

  • 2 - Using the Schrödinger Wave Equation

  • A. F. J. Levi, University of Southern California
  • Book:
    Applied Quantum Mechanics
    Published online:
    27 October 2023
    Print publication:
    31 August 2023, pp 55-104

  • Summary

    According to the Schrödinger equation, a particle with wave character and mass m in the presence of a potential may be described as a state that is a function of space and time. Space and time are assumed to be smooth and continuous. The potential can localize the particle to one region of space forming a bound state.

  • 4 - Eigenstates and Operators

  • A. F. J. Levi, University of Southern California
  • Book:
    Applied Quantum Mechanics
    Published online:
    27 October 2023
    Print publication:
    31 August 2023, pp 170-224

  • Summary

    Quantum mechanics is a very successful description of atomic scale systems. The mathematical formalism relies on the algebra of noncommuting linear Hermitian operators. Postulates provide a logical framework with which to make contact with the results of experimental measurements.

  • 11 - Toward Quantum Engineering

  • A. F. J. Levi, University of Southern California
  • Book:
    Applied Quantum Mechanics
    Published online:
    27 October 2023
    Print publication:
    31 August 2023, pp 481-521

  • Summary

    It is possible to engineer properties of materials, devices, and systems by changing experimentally available control parameters to optimally approach a specific objective. The following sections demonstrate some potential applications of quantum engineering and show how this may be achieved by the development of efficient physical models combined with optimization algorithms.

  • 10 - Angular Momentum and the Hydrogenic Atom

  • A. F. J. Levi, University of Southern California
  • Book:
    Applied Quantum Mechanics
    Published online:
    27 October 2023
    Print publication:
    31 August 2023, pp 432-480

  • Summary

    In classical mechanics, the constants of motion of an isolated system are energy, linear momentum, and angular momentum. So far in this book, angular momentum has not been considered. This chapter starts by defining classical angular momentum and then proceeds to find the corresponding quantum operators. Following this, a hydrogenic atom is studied as a prototype application.

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