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3 results

  • Chapter 10 - In search of estrogen alternatives for the brain

  • from Section 2 - Varieties of estrogenic therapy
  • Edited by Eef Hogervorst, Loughborough University, Victor W. Henderson, Stanford University, California, Robert B. Gibbs, University of Pittsburgh, Roberta Diaz Brinton, University of Southern California
  • Book:
    Hormones, Cognition and Dementia
    Published online:
    06 July 2010
    Print publication:
    24 September 2009, pp 93-100

  • Summary

    Editors' introduction

    This chapter briefly reviews recent advancements in the search for a non-feminizing estrogen alternative that can mimic estrogen's positive effects on cognitive health without eliciting an undesirable impact on reproductive and cardiovascular systems. The discussion focuses on two avenues of translational development, tissue-selective and subtype-selective estrogen receptor (ER) modulators (SERMs), in particular ERβ-selective phytoSERMs as a natural approach for potentially promoting neurological health and preventing age-associated cognitive impairment and risk of Alzheimer's disease in both genders.