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Epidemiological analysis of 3,219 COVID-19 outbreaks in the state of Baden-Wuerttemberg, Germany
- Aparna Dressler, Iris Finci, Christiane Wagner-Wiening, Martin Eichner, Stefan O Brockmann
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- Journal:
- Epidemiology & Infection / Volume 149 / 2021
- Published online by Cambridge University Press:
- 23 April 2021, e101
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- Article
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emerged as an unprecedented global crisis challenging health systems. This paper aims to assess and characterise SARS-CoV-2 outbreaks in the state of Baden-Wuerttemberg to identify groups at greatest risk, to establish early measures to curb transmission. We analysed all mandatory notified (i.e. laboratory-confirmed) coronavirus disease (COVID-19) outbreaks with more than two cases in Baden-Wuerttemberg from calendar weeks 18–49 (from 27 April to 6 December 2020). We used the following classification for settings: asylum and refugee accommodation, care homes, care facilities, day care child centres, hobby-related, hospitality, hospitals, households, other, residence halls, schools, supported housing, training schools, transportation, treatment facilities and workplace (occupational). We used R program version 3.6.3 for analysis. In our analysis, 3219 outbreaks with 22 238 individuals were included. About 48% were in household and hobby-related settings. Care homes accounted for 9.5% of outbreaks and 21.6% of cases. The median age across all settings was 43 (interquartile range (IQR) 24–63). The median age of cases in care homes was 81 (IQR 56–88). Of all reported cases in care homes, 72.1% were women. Over 30% (466/1511) of hospitalisations were among cases in care homes compared to 17.7% (268/1511) in households. Overall, 70% (500/715) of all deceased persons in outbreaks in the study period were in care homes compared to 4.2% in household settings (30/715). We observed an exponential increase in the number of notified outbreaks starting around the 41st week with N = 291 outbreaks reported in week 49. The median number of cases in outbreaks in care homes and care facilities after the 40th week was 14 (IQR 5–29) and 11 (IQR 5–20), respectively, compared to 3 (IQR 3–5) in households. We observed an increase in hospitalisations, and mortality associated with COVID-19 outbreaks in care homes after the 40th week. We found the care home demographic to be at greatest risk after the 40th week, based on the exponential increase in outbreaks, the number of cases, hospitalisations and mortality trends. Our analysis highlights the necessity of targeted, setting-specific approaches to control transmission in this vulnerable population. Regular screening of staff members and visitors' using rapid antigen point-of-care-tests could be a game-changer in curbing transmission in this setting.
An age-structured model for measles vaccination
- Edited by Valerie Isham, University College London, Graham Medley, University of Warwick
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- Book:
- Models for Infectious Human Diseases
- Published online:
- 04 August 2010
- Print publication:
- 29 March 1996, pp 38-56
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Summary
Introduction
If a fraction of a population is vaccinated, the spread of the infective agent is slowed down and consequently the incidence of infection for non-vaccinated persons is reduced. If the vaccine itself carries some risk then the risk of illness for a non-vaccinated person can drop below that for a vaccinated one. This occurs when the spread of infection has been greatly reduced by vaccination. It then becomes questionable whether people will agree to be vaccinated and whether, therefore, an infectious disease can be eliminated by vaccination on a voluntary basis. With smallpox vaccination it was shown that in the final years of the campaign more cases of illness were caused in the US by vaccination than by infections (CDC 1971) and nowadays there is a lively discussion about the oral poliomyelitis vaccines which have been incriminated in causing more paralytic cases in the US than the rare wild viruses do (Beale 1990, Begg et al 1987, Cossart 1977, McBean and Modlin 1987). Fine and Clarkson (1986) were the first to compare the risk of illness of vaccinated persons with that of non-vaccinated ones from a theoretical point of view. To estimate the incidence of infection that results from a given vaccination coverage, they made arbitrary assumptions which imply that an infection can only be eliminated if 100 percent of the population are effectively immunized. Moreover, they did not take into consideration an age-specific conditional probability of illness or death upon infection. Many of the so-called ‘childhood diseases’ tend to be more serious in adults than in infants.