Little research has considered fuzzy scheduling and sequencing problem in operating rooms. Multiple-period fuzzy scheduling and sequencing of patients in operating rooms optimization models are proposed in this research taking into consideration patient‘s preference. The objective of the scheduling optimization model is obtaining minimal undertime and overtime and maximum patients' satisfaction about the assigned date. The objective of sequencing the optimization model is both to minimize overtime and to maximize patients' satisfaction about the assigned time. A real-life case study from a hospital that offers comprehensive surgical procedures for all surgical specialties is considered for illustration. Research results showed that the proposed models efficiently scheduled and sequenced patients while considering their preferences and hospitals operating costs. In conclusion, the proposed optimization models may result in improving patient satisfaction, utilizing hospital's resources efficiently, and providing assistance to decision makers and planners in solving effectively fuzzy scheduling and sequencing problems of operating rooms.