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Background

We compared three doses of a neuroleptic as a treatment for mania.

Method

Forty-seven newly admitted in-patients with mania were randomised to receive 10, 30, or 80 mg a day of oral haloperidol, under double-blind conditions for up to six weeks. All subjects received prophylactic benztropine.

Results

Repeated-measures analysis of variance and survival analysis showed no difference in outcome by the different doses. Excluding drop-outs (38%), most of whom left the study during the first two weeks, 72% of the subjects responded. Side-effects were minimal; there were no differences among the three doses. Non-responders received more adjunctive lorazepam than responders.

Conclusions

The limited data suggest that more than 10 mg a day of haloperidol offers no advantage in mania.

This article reviews eight published studies that describe clozapine's effects on TD and examines the outcome of 30 patients with TD treated with clozapine for up to 36 months. These data indicate that TD response to clozapine is variable but that approximately 43% of cases, particularly those with dystonic features, improved after clozapine treatment. Methodological limitations of the studies described, however, preclude definitive conclusions, which must await appropriately controlled trials.

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Dosage of Haloperidol for Mania

The Effects of Clozapine on Tardive Dyskinesia

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2 results

Dosage of Haloperidol for Mania

The Effects of Clozapine on Tardive Dyskinesia