Endoplasmic reticulum stress and lipid dysregulation

Stephen M. Colgan; Ali A. Al-Hashimi; Richard C. Austin

doi:10.1017/S1462399410001742

Endoplasmic reticulum stress and lipid dysregulation

Published online by Cambridge University Press: 03 February 2011

Stephen M. Colgan ,

Ali A. Al-Hashimi and

Richard C. Austin

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Stephen M. Colgan: Affiliation:
Department of Medicine and Division of Nephrology, St Joseph's Healthcare Hamilton and McMaster University, Hamilton, Ontario, Canada.
Ali A. Al-Hashimi: Affiliation:
Department of Medicine and Division of Nephrology, St Joseph's Healthcare Hamilton and McMaster University, Hamilton, Ontario, Canada.
Richard C. Austin*: Affiliation:
Department of Medicine and Division of Nephrology, St Joseph's Healthcare Hamilton and McMaster University, Hamilton, Ontario, Canada.
*: *Corresponding author: Richard C. Austin, 50 Charlton Avenue East, Room T-3313, Hamilton, Ontario, CanadaL8N 4A6. E-mail: austinr@taari.ca

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Abstract

Cellular cholesterol homeostasis is a fundamental and highly regulated process. Transcription factors known as sterol regulatory element binding proteins (SREBPs) coordinate the expression of many genes involved in the biosynthesis and uptake of cholesterol. Dysregulation of SREBP activation and cellular lipid accumulation has been associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 13 , March 2011 , e4

DOI: https://doi.org/10.1017/S1462399410001742 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2011

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Endoplasmic reticulum stress and lipid dysregulation

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