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Evaluation of set-up errors and estimation of set-up margin during external beam radiation therapy of prostate cancer using electronic portal imaging device (EPID)

Published online by Cambridge University Press:  22 April 2021

Daryoush Khoramian Open the ORCID record for Daryoush Khoramian [Opens in a new window] ,
Soroush Sistani  and
Bagher Farhood
Daryoush Khoramian*
Affiliation:
Medical Physics Department, Ramezan Zadeh Radiotherapy Center, Yazd, Iran Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran
Soroush Sistani
Affiliation:
Medical Physics Department, Ramezan Zadeh Radiotherapy Center, Yazd, Iran Department of Medical Physics, The Advocate Center for Clinical Research, Ayatollah Yasrebi Hospital, Kashan, Iran
Bagher Farhood
Affiliation:
Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
*
Author for correspondence: Daryoush Khoramian, Medical Physics Department, Ayatollah Yasrebi Hospital, Kashan, Iran, Tel: +98 9378394640. E-mail: daryoushkhoramian@gmail.com
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Abstract

Aim:

In radiation therapy, accurate dose distribution in target volume requires accurate treatment setup. The set-up errors are unwanted and inherent in the treatment process. By achieving these errors, a set-up margin (SM) of clinical target volume (CTV) to planning target volume (PTV) can be determined. In the current study, systematic and random set-up errors that occurred during prostate cancer radiotherapy were measured by an electronic portal imaging device (EPID). The obtained values were used to propose the optimum CTV-to-PTV margin in prostate cancer radiotherapy.

Materials and methods:

A total of 21 patients with prostate cancer treated with external beam radiation therapy (EBRT) participated in this study. A total of 280 portal images were acquired during 12 months. Gross, population systematic (Σ) and random (σ) errors were obtained based on the portal images in Anterior–Posterior (AP), Medio-Lateral (ML) and Superior–Inferior (SI) directions. The SM of CTV to PTV were then calculated and compared by using the formulas presented by the International Commission on Radiation Units and Measurements (ICRU) 62, Stroom and Heijmen and Van Herk et al.

Results:

The findings showed that the population systematic errors during prostate cancer radiotherapy in AP, ML and SI directions were 1·40, 1·95 and 1·94 mm, respectively. The population random errors in AP, ML and SI directions were 2·09, 1·85 and 2·29 mm, respectively. The SM of CTV to PTV calculated in accordance with the formula of ICRU 62 in AP, ML and SI directions were 2·51, 2·68 and 3·00 mm, respectively. And according to Stroom and Heijmen, formula were 4·23, 5·19 and 5·48 mm, respectively. And Van Herk et al. formula were 4·96, 6·17 and 6·45 mm, respectively.

Findings:

The SM of CTV to PTV in all directions, based on the formulas of ICRU 62, Stroom and Heijmen and van Herk et al., were equal to 2·73, 4·98 and 5·86 mm, respectively; these values were obtained by averaging the margins in all directions.

Keywords

3DCRTEPIDprostate cancerset-up errorsset-up margin
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 4 , December 2022 , pp. 493 - 500
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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