Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Comparing in vitro 2D and 3D-tumor model of triple-negative breast cancer

Michael M. Lübtow; Lena C. Nelke; Anna Brown; Gaurav Sahay; Gudrun Dandekar; Robert Luxenhofer

doi:10.26434/chemrxiv.5661736.v1

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Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Comparing in vitro 2D and 3D-tumor model of triple-negative breast cancer

05 December 2017, Version 1

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This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

This manuscript describes a ultra-high loaded nanoformulation of curcumin. This compound is extremely water insoluble but could be dissolved using poly(2-oxazoline)/poly(2-oxazine) based polymer amphiphiles. The resulting formulations were thoroughly characterized in solution and solid form by NMR, dynamic light scattering, electron microscopy, HPLC zeta potential measurements, XRD, respectively. Biological activity was ensured and compared in 2D and 3D cell culture.

Keywords

solid amorphous dispersion

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Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models

Michael M. Lübtow, Lena C. Nelke, Julia Seifert, Johanna Kühnemundt, Gaurav Sahay, Gudrun Dandekar, Sarah L. Nietzer, Robert Luxenhofer journal article

Journal of Controlled Release , Volume 303

Print publication date: Jun, 2019

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DOI

10.26434/chemrxiv.5661736.v1

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No conflict declared

Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Comparing in vitro 2D and 3D-tumor model of triple-negative breast cancer

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