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Optoregulated Drug Release from an Engineered Living Hydrogel

14 September 2018, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A living hydrogel has been developed with metabolically and optogenetically engineered E. coli encapsulated within an agarose-based hydrogel matrix to produce and release deoxyviolacein in response to blue light irradiation. Localized, tunable and prolonged drug release have been demonstrated.

Keywords

Hydrogel
E. coli
Deoxyviolacein
Optogenetics
Metabolic Engineering
Controlled Release

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Now Published

Optoregulated Drug Release from an Engineered Living Material: Self‐Replenishing Drug Depots for Long‐Term, Light‐Regulated Delivery [opens in a new tab]
Shrikrishnan Sankaran, Judith Becker, Christoph Wittmann, Aránzazu del Campo journal article
Small , Volume 15, Issue 5
Online publication date: Dec 27, 2018

Version History

Sep 14, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.7087010.v1
D O I: 10.26434/chemrxiv.7087010.v1 [opens in a new tab]

Funding

DFG SFB1027

Author’s competing interest statement

The authors declare no conflict of interests

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