Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly

Essak Khan; Shrikrishnan Sankaran; Julieta Paez; Christina Muth; Mitchell Han; Aránzazu del Campo

doi:10.26434/chemrxiv.6964703.v3

Biological and Medicinal Chemistry

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Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly

18 October 2018, Version 3

Working Paper

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This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.

Keywords

Collagen

Hsp47

KDEL Receptor Mediated Endocytosis

Biological activity

Photoactivation

Optoregulation

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