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A Convenient Two-Step Synthesis of Coenzyme Q1

15 May 2019, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A convenient method for the preparation of Coenzyme Q1 from the cheap and readily available 3,4,5-Trimethoxytoluene was developed. CoQ1 was synthesized in moderate yield by a two-step procedure involving the key reaction of allyl bromide with CoQ0 through a redox chain reaction. The reaction is efficient and could be used for the synthesis of other CoQ compounds.

Keywords

Coenzyme Q
chain reaction

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Version History

May 15, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.8115932.v1
D O I: 10.26434/chemrxiv.8115932.v1 [opens in a new tab]

Author’s competing interest statement

no conflict of interest

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