Utilizing Carbonyl-Coordination of Native Amides for Pd– catalyzed C(sp3)–H Olefination

Pd(II)–catalyzed C(sp³)–H olefination of native amide substrates was developed. To utilize the extremely

weak-coordinating carbonyl-coordination of amides, an electron-deficient pyridinesulfonic acid ligand

was designed. Structurally diverse amide substrates, including lactams, underwent olefination without the

undesired cyclization. Olefination products were further diversified through synthetic transformations on

the alkenyl moiety.