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Controlled Release of Ibuprofen from Polymeric Nanoparticles

24 September 2019, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

Keywords

ROMP
ibuprofen
controlled release
ring-opening metathesis polymerisation

Supplementary materials

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Controlled release of ibuprofen from polymeric nanoparticles - ESI
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Now Published

Architecture-controlled release of ibuprofen from polymeric nanoparticles [opens in a new tab]
Sara Shehata, Christopher J. Serpell, Stefano C.G. Biagini journal article
Materials Today Communications , Volume 25
Print publication date: Dec, 2020

Version History

Sep 24, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.9884114.v1
D O I: 10.26434/chemrxiv.9884114.v1 [opens in a new tab]

Funding

School of Physical Sciences, University of Kent Graduate Training Scheme, and the EPSRC Doctoral Training Programme

Author’s competing interest statement

No conflict of interest

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