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Monitoring Polymer-Assisted Mechanochemical Cocrystallisation Through in Situ X-Ray Powder Diffraction

19 March 2020, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Time-resolved mechanochemical cocrystallisation studies have so-far focused solely on neat and liquid-assisted grinding. Here, we report the monitoring of polymer-assisted grinding reactions using in situ X-ray powder diffraction, revealing that reaction rate is almost double compared to neat grinding and independent of the molecular weight and amount of used polymer additives.

Keywords

Mechanochemistry
Polymer-assisted grinding
Cocrystallisation
In situ X-ray powder diffraction
Reaction mechanism

Supplementary materials

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Now Published

Monitoring polymer-assisted mechanochemical cocrystallisation through in situ X-ray powder diffraction [opens in a new tab]
Luzia S. Germann, Sebastian T. Emmerling, Manuel Wilke, Robert E. Dinnebier, Mariarosa Moneghini, Dritan Hasa journal article
Chemical Communications , Volume 56, Issue 62
Online publication date: 2020

Version History

Mar 19, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11996589.v1
D O I: 10.26434/chemrxiv.11996589.v1 [opens in a new tab]

Funding

Swiss National Science Foundation (P2SKP2_187638)
University of Trieste (FRA 2020)

Author’s competing interest statement

no conflict of interest

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