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Abstract
A new route to MK-4482 (1) was developed. The route
replaces uridine with the more available and less expensive cytidine. Low cost, simple reagents are used for the
chemical transformations and the yield is improved from 17% to 44%. A step is removed from the longest linear
sequence, and these advancements are expected to expand access to MK-4482
should it become a viable drug substance.
Supplementary materials
Title
2020 09 08 EIDD Cytidine Acetonide SI
Description
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