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Nanohoop Rotaxane Design to Enhance Selectivity of Reaction Based Probes: A Proof of Principle Study

16 September 2020, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A novel fluorescent probe design based on the interlocking of a reactive thread in a rigid nanohoop fluorophore is reported. This rotaxane design leads to size-selective sensing of thiolates in organic solution. More broadly, the work suggests the promise of mechanical interlocking to enhance the selectivity of reaction-based probes.

Keywords

cycloparaphenylenes
nanohoops
rotaxane
fluorescent probe
sensor

Supplementary materials

Title
Description
Actions
Title
H2S rotaxane SI
Description
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Now Published

Nanohoop Rotaxane Design to Enhance the Selectivity of Reaction-Based Probes: A Proof-of-Principle Study [opens in a new tab]
Claire E. Otteson, Carolyn M. Levinn, Jeff M. Van Raden, Michael D. Pluth, Ramesh Jasti journal article
Organic Letters , Volume 23, Issue 12
Online publication date: Jun 01, 2021

Version History

Sep 16, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12960167.v1
D O I: 10.26434/chemrxiv.12960167.v1 [opens in a new tab]

Funding

CHE-1808791
National Institute of General Medical Sciences
R01GM113030
Chemical Tools for Delivery and Detection of Biological Hydrogen Sulfide
https://app.dimensions.ai/details/grant/grant.4243253 [opens in a new tab]
DGE-1309047

Author’s competing interest statement

There are no conflicts to declare.

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