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In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

25 September 2020, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

This work describes the in vitro binding of CB[8] and Me4CB[8] toward a panel of 10 drugs of abuse, and in vitro and in vivo assays to demonstrate the biocompatibility of Me4CB[8]. In vivo efficacy studies show that Me4CB[8] can control the hyper locomotion of animals treated with PCP.

Keywords

cucurbituril
sequestration agent
phencyclidine hydrochloride
molecular recognition
hyperlocomotion assay

Supplementary materials

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Title
Me4CB8 Reversal Paper SI 20200922 pdfa
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Now Published

In Vitro and In Vivo Sequestration of Phencyclidine by Me 4 Cucurbit[8]uril** [opens in a new tab]
Steven Murkli, Jared Klemm, Adam T. Brockett, Michael Shuster, Volker Briken, Matthew R. Roesch, Lyle Isaacs journal article
Chemistry – A European Journal , Volume 27, Issue 9
Online publication date: Jan 19, 2021

Version History

Sep 25, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12994004.v1
D O I: 10.26434/chemrxiv.12994004.v1 [opens in a new tab]

Funding

National Institutes of Health (GM132345 and CA168365)
National Science Foundation (CHE-1404911)
Department of Education (GAANN, P200A150033)

Author’s competing interest statement

The University of Maryland has filed a patent on the material presented in this paper with S.M. and L.I. named as inventors.

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