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Molecular Mapping of Neutral Lipids using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry

16 March 2021, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Our work demonstrates the ability to perform high spatial resolution imaging mass spectrometry (IMS) using silicon nanopost arrays (NAPA), a matrix-free laser desorption ionization (LDI) substrate, for multiple classes of neutral lipids from biological tissue sections.


Utilized trapped ion-mobility spectrometry (TIMS) coupled with IMS to enhance the molecular coverage of detected neutral lipid species, as well as for differentiating neutral lipid isomeric species spatial distributions.

Keywords

mass spectrometry
lipids
ion mobility
laser desorption ionization

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Now Published

Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry [opens in a new tab]
Jarod A. Fincher, Katerina V. Djambazova, Dustin R. Klein, Martin Dufresne, Lukasz G. Migas, Raf Van de Plas, Richard M. Caprioli, Jeffrey M. Spraggins journal article
Journal of the American Society for Mass Spectrometry , Volume 32, Issue 10
Online publication date: Aug 26, 2021

Version History

Mar 16, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14216963.v1
D O I: 10.26434/chemrxiv.14216963.v1 [opens in a new tab]

Author’s competing interest statement

No conflict of interest

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