How to Submit
Browse
Events
Communities
About

Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes

12 July 2021, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.

Keywords

Alkene Isomerization
Directing Group
Tungsten
Hydroboration
Chain-Walking
Organoboron

Supplementary materials

Title
Description
Actions
Title
Supporting Info
Description
Experimental Procedures, Analytical Data, and Copies of NMR Spectra
Actions
Title
2b.cif
Description
Crystallographic Information File - Compound 2b
Actions
Title
2i.cif
Description
Crystallographic Information File - Compound 2i
Actions
Title
2n.cif
Description
Crystallographic Information File - Compound 2n
Actions
Title
3b.cif
Description
Crystallographic Information File - Compound 3b
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting and Discussion Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes [opens in a new tab]
Tanner C. Jankins, Raul Martin-Montero, Phillippa Cooper, Ruben Martin, Keary M. Engle journal article
Journal of the American Chemical Society , Volume 143, Issue 37
Online publication date: Sep 09, 2021

Version History

Jul 12, 2021 Version 1

Metrics

2,653
1,200
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-kn5xp
D O I: 10.26434/chemrxiv-2021-kn5xp [opens in a new tab]

Funding

National Institutes of Health
5R35GM125052-04
English-Speaking Union
La Caixa
FEDER/MICIU
AEI/PGC2018-096839-B-100
MCI/AIE
CEX2019-000925-S

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share