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Palladium Catalyzed syn-1,2-ArylMethylation of Internal Alkynes

15 November 2022, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A Pd-catalyzed syn-1,2-arylmethylation of internal alkynes (ynamides/ yne-acetates) is described. The readily available and bench stable coupling partners iodo-arenes, and methyl boronic acid are successfully being used to access the methyl containing tetra substituted olefins; notably, the transformation is regio as well stereoselective. The scope is broad (52 examples), showing excellent functional-group tolerance. Finally, synthetic manifestations of the products were also demonstrated.

Keywords

Methylation
Difunctionalization
Alkyne

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Version History

Nov 15, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-z9kq4
D O I: 10.26434/chemrxiv-2022-z9kq4 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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