How to Submit
Browse
Events
Communities
About

BHAS Coupling of Aryl Halides to Arenes Facilitated by Nickel Complexes

16 May 2023, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Aryl halides are efficiently coupled to benzene using air-stable Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone) and KOtBu, without additional ligands. Mechanistic evidence suggests that Ni(COD)(DQ) and KOtBu act as an initiation source, forming aryl radicals that then react with the arene via base-assisted homolytic aromatic substitution.

Keywords

Ni(COD)(DQ)
coupling
BHAS
radical
KOtBu

Supplementary materials

Title
Description
Actions
Title
SI for "BHAS Coupling of Aryl Halides to Arenes Facilitated by Nickel Complexes"
Description
Spectroscopic and Chromatographic supplementary information
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting and Discussion Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

May 16, 2023 Version 1

Metrics

1,215
534
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-z112p
D O I: 10.26434/chemrxiv-2023-z112p [opens in a new tab]

Funding

EPSRC
GSK

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share