STOPLIGHT: A Hit Scoring Calculator

We introduce STOPLIGHT, a web portal to assist medicinal chemists in prioritizing hits from screening campaigns and selection of compounds for optimization. STOPLIGHT incorporates services to assess 6 physiochemical and structural properties, 6 assay liabilities, and 11 pharmacokinetic properties for any small molecule represented by its SMILES string. We briefly describe each service and illustrate the utility of this portal with a case study. The STOPLIGHT portal provides a user-friendly tool to guide hit selection in early drug discovery campaigns, whereby compounds with unfavorable properties can be quickly recognized and eliminated. Availability and implementation: STOPLIGHT is freely accessible at https://stoplight.mml.unc.edu/.