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Abstract
The formation of Grignard reagents from metallic magnesium and a halide is often accompanied by the formation of the Wurtz coupling product, an undesired side product formed by the reaction of a Grignard reagent molecule and a halide molecule. By using a scale-up approach from semi-batch type synthesis to continuous lab and pilot scale for various Grignard reagents, it is demonstrated that a continuous production process can improve Grignard reagent selectivity and reduce Wurtz coupling.
Supplementary materials
Title
Selectivity of Grignard reagent formation – from semi-batch to continuous lab and pilot scale
Description
Reaction conditions, analytical data, and infrared spectra specific for each Grignard reagent, temperature profiles for benzylmagnesium bromide synthesis (PDF)
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