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Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis

04 December 2023, Version 2
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Six undescribed cephalotane-type diterpenoids and/or norditerpenoids, ceforloids A–F (1–6), were isolated from Cephalotaxus fortunei var. alpina and C. sinensis. Their structures were elucidated by comprehensive analysis of spectroscopic data. Compound 1 possesses an unprecedented norditerpenoid skeleton featuring an unusual acetophenone moiety, and originated putatively from a disparate biogenetic pathway. Compounds 4 and 5 incorporate a unique 12,13-p-hydroxybenzylidene acetal motif. Compound 6 is a rare cephalotane-type diterpenoid glycoside. Immunosuppressive assays showed that compounds 2 and 6 exhibited mild suppressive activity against the activated T and B lymphocytes proliferation.

Keywords

cephalotane
ceforloid
diterpenoid
immunosuppressive
Cephalotaxus

Supplementary materials

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Description
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Supporting Information
Description
IR, MS, NMR, and ECD spectra of compounds 1-7; key 2D NMR correlations of compounds 2, 3, 5 and 7; and computational details for compounds 2 and 3 (PDF)
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Now Published

Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis [opens in a new tab]
Zhan-Peng Ge, Jin-Biao Xu, Peng Zhao, Mai Xiang, Yu Zhou, Ze-Min Lin, Jian-Ping Zuo, Jin-Xin Zhao, Jian-Min Yue journal article
Phytochemistry , Volume 221
Print publication date: May, 2024

Version History

Dec 04, 2023 Version 2

Version Notes

Two new authors have been added. Details for the immunosuppressive assay have also been added. The manuscript was revised according to the requirement of the journal "Phytochemistry".

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-8v6dr-v2
D O I: 10.26434/chemrxiv-2023-8v6dr-v2 [opens in a new tab]

Funding

National Natural Science Foundation of China
22237007, T2192972
Youth Innovation Promotion Association of the Chinese Academy of Sciences
2022282, 2023293
Biological Resources Program of Chinese Academy of Sciences
KFJ-BRP-008-001

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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