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Lipase enzymes for sustainable synthesis of chiral active pharmaceutical ingredients (API) and key starting materials

18 January 2024, Version 1
Review
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Biocatalysis is considered as a green and sustainable process for synthesis of chiral organic building blocks and active pharmaceutical ingredients (API). Lipase catalysed kinetic and kinetic dynamic resolution process is frequently used for in API or KSM synthesis. This review describes the reported synthesis of chiral API/KSM molecules using lipase enzyme, since last 10 years.

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Version History

Jan 18, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-km1k1
D O I: 10.26434/chemrxiv-2024-km1k1 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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