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Abstract
Herein, we report a mild transition metal-free organophotoredox catalyzed approach for β-hydroxytrifluoromethylation of unactivated alkenes using CF3SO2Na and acridinium salt. The protocol is compatible with various mono, di- and tri-substituted aliphatic unactivated alkenes containing numerous functional groups and natural product derivatives. Further, the post-synthetic modifications of synthesized trifluoromethylated products have been demonstrated through cross-coupling and functional group interconversion reactions. The method proved to be scalable and also it works smoothly un-der direct exposure of sunlight. A plausible mechanism has been proposed based on fluorescence quenching experiment and cyclic voltammetry analysis.
Supplementary materials
Title
Visible Light Induced Organophotoredox Catalyzed β-Hydroxytrifluoromethylation of Unactivated Alkenes
Description
The supporting information gives a detailed general experimental procedures, experimental data and copies of proton, flourine and carbon NMR spectra. Gives a deatiled control experiments as well. This ESI also gives single crystal X-ray diffraction data, cyclic voltammograms, fluorescence quenching experiments etc. .
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