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A New Reagent to Access Methyl Sulfones

17 April 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A new chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.

Keywords

heterocycles
medicinal chemistry
methyl sulfone
bicyclo[1.1.1]pentane
fluorine

Supplementary materials

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Supporting Information
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Detailed experimentals procedures, copies of NMR spectra.
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Version History

Apr 17, 2024 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-3lxgq
D O I: 10.26434/chemrxiv-2024-3lxgq [opens in a new tab]

Author’s competing interest statement

Authors of this works are employees of a chemical supplier Enamine.

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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