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Sphingosine pathway as a possible druggable target for pain management

16 July 2024, Version 1
Review
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Sphingolipids bear a spingoid base, and a fatty amino alcohol known as sphingosine. Sphingosine in converted to sphingosine phosphate (S1P) catalyzed by sphingosine kinase enzymes. S1P is transported across the plasma membrane and binds to extracellular S1P receptors. S1P is found in high concentration in plasma of patients with rheumatoid arthritis and at inflammation sites. Targeting S1P receptors might be a suitable strategy for discovery of drugs for treatment of neuropathic pain.

Keywords

Sphingosine
ceramide
neuropathic pain
diabetic neuropathy
drug discovery

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Version History

Jul 16, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-dp7gz
D O I: 10.26434/chemrxiv-2024-dp7gz [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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