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Electrochemical trifluoromethylation of enamides under microflow conditions

02 August 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

The development of sustainable trifluoromethylations of enamides is of great interest to the pharmaceutical industry. Herein, we demonstrate a sustainable direct electrochemical trifluoromethylation method in a microflow cell, using Langlois reagent, without the need of a supporting electrolyte, oxidants or any additive under mild conditions. This method can be applied to various substrates with a yield up to 84%.

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ESI containing general experimental data, additional optimisation data, and characterisation of compounds.
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Now Published

Electrochemical Trifluoromethylation of Enamides under Microflow Conditions [opens in a new tab]
Anna Vanluchene, Tomas Horsten, Eli Bonneure, Christian V. Stevens journal article
Organic Process Research & Development , Volume 28, Issue 11
Online publication date: Oct 22, 2024

Version History

Aug 02, 2024 Version 1

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-069lr
D O I: 10.26434/chemrxiv-2024-069lr [opens in a new tab]

Funding

European Union’s Horizon 2022, Marie Skłodowska-Curie grant
101063994

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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