Radical-Nucleophilicity Controlled Regiodivergent C-3 vs C-7 Functionalization of Quinoxalin-2(1H)-ones

Here in this article, we have addressed how radical nucleophilicity and temperature controlled the regiodiversity (C-3 vs C-7) of quinoxalin-2(1H)-one. Following the acquisition of the diversity product, PTSA and potassium carbonate were added within the reaction vessel to further address the selectivity issue for the same methods. And we encompassed an easy-to-follow guide explaining how to obtain 7-bromo-1-methylquinoxalin-2(1H)-one and 2-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide using 1-methylquinoxalin-2(1H)-one and 2-bromobenzo[d]isothiazol-3(2H)-one 1,1-dioxide in acetonitrile solvent.