How to Submit
Browse
Events
Communities
About

Oxoammonium-Catalyzed Oxidation of N-Substituted Amines

26 August 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

We report the development of oxoammonium-catalyzed oxidation of N-substituted amines via a hydride transfer mechanism. Steric and electronic tuning of catalyst led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides. The reaction was further demonstrated on a 100-g scale using a continuous flow setup.

Keywords

Oxidation
Oxoammonium
Aminoxyl radical
C–H activation
Flow
High-throughput experimentation
Data science

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting and Discussion Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Aug 26, 2024 Version 1

Metrics

2,684
2,245
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-brd62
D O I: 10.26434/chemrxiv-2024-brd62 [opens in a new tab]

Funding

NIH
R01 GM134088
Boehringer Ingelheim Pharmaceuticals, Inc.
Dreyfus Foundation
Teacher-Scholar Award
NSF
CHE-1531632

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share