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Batch and continuous synthesis of 5,5-diphenylhydantoin, an active pharmaceutical ingredient

16 October 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A teaching laboratory protocol was developed for the implementation of an ultrasound-assisted continuous-flow synthesis of 5,5-diphenylhydantoin, a drug used for epilepsy and tonic-clonic seizures. This methodology allowed students to understand concepts of green chemistry, ultrasound irradiation, continuous flow chemistry and drug synthesis.

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Version History

Oct 16, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-rrp4p
D O I: 10.26434/chemrxiv-2024-rrp4p [opens in a new tab]

Funding

Fundação para a Ciência e Tecnologia (FCT)
2022.08559.PTDC

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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