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Analysis of adenosine phosphonucleotides in blood by nh-PHIP

16 October 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

The sensitivity of conventional NMR is limited to metabolites at mid-micromolar concentrations, however diagnostically relevant metabolites are often found at lower concentrations. nh-PHIP has shown promise for analyzing complex biological samples like urine, but adapting it to blood presents additional challenges due to its complex matrix. Herein we successfully demonstrate the use of nh-PHIP for detecting adenine phosphonucleotides in blood.

Keywords

nhPHIP
parahydrogen
blood
adenosine phosphonucleotides

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Version History

Oct 16, 2024 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-kr41w
D O I: 10.26434/chemrxiv-2024-kr41w [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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