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A step towards exploring the potential of organosilane for catalytic amidation

20 November 2024, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Trimethoxyphenylsilane catalysed amidation protocol demonstrated for amide synthesis in refluxing toluene. The desired amide product is obtained by a simple acid-base workup protocol with moderate to good yield up to 67%. Without need of any dehydrating agent under simple azeotropic reflux condition make this protocol attractive for amidation reaction. Compatibility of trimethoxyphenyl silane with challenging aromatic acid and amine demonstrates its catalytic potency for amidation reactions.

Keywords

Amidation
Silica Catalyst
Organosilane
Acid-Amine
Amide
Green Chemistry

Supplementary materials

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Supporting Information File
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Experimental procedures, characterisation data, NMR spectra,
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Version History

Nov 20, 2024 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-cq8cs
D O I: 10.26434/chemrxiv-2024-cq8cs [opens in a new tab]

Funding

CSIR−New Delhi
senior research fellowship
Department of Science and Technology (DST), India
DST INSPIRE Faculty Award IFA17-CH260
CSIR NCL Pune
MLP 037926 Start Up-Project

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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