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Abstract
Though thioamides are considered weaker hydrogen-bond acceptors than oxoamides, recent calculations suggest they might enhance hydrogen bonds within the backbone of individual β-strands. We confirm this prediction through spectroscopic analysis of minimal amino-acid models. Further, incorporation of thioamides into the backbone of β-hairpin models high-lights opportunities to control β-strand stability.
Supplementary materials
Title
Supporting information
Description
Synthetic and analytical methods, characterization data for small molecules and peptides.
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