Achieving versatile Cu-catalyzed multicomponent 1,1-aminosilylation reactions from feedstock reagents

1,1-aminosilanes are emerging as valuable reagents for diversification efforts while also showing potential for silicon-based drug develop-ment. However, no strategies exist to access broad libraries of structurally and electronically diverse1,1-aminosilanes from readily available materials. Herein, we disclose a Cu-catalyzed multicomponent reaction for the direct synthesis of 1,1-aminosilanes from simple feedstock chemicals. This method provides a high yielding, cost-effective, operationally simple, and scalable approach with broad functional group tolerance. Compatible with both aliphatic and aromatic aldehydes as well as primary and secondary amines, it also enables late-stage modifications of FDA approved drugs and their precursors, unlocking new opportunities in pharmaceutical and materials science.